35531-58-9

Basic information

• Product Name: 1,3-Dithiane, 2-(2-nitrophenyl)-
• CAS NO: 35531-58-9
• Molecular Formula: C10H11NO2S2
• Molecular Weight: 241.335
• Mol File: 35531-58-9.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 1,3-Dithiane, 2-(2-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dithiane, 2-(2-nitrophenyl)-(35531-58-9)
• EPA Substance Registry System: 1,3-Dithiane, 2-(2-nitrophenyl)-(35531-58-9)

Safety Data

• Hazardous Substances Data: 35531-58-9(Hazardous Substances Data)

Upstream product

• 505-23-7 1,3 dithiane 
• 98-95-3 nitrobenzene 
• 109-80-8 1.3-propanedithiol 
• 552-89-6 2-nitro-benzaldehyde 
• 48140-35-8 2-(2-nitrophenyl)-1,3-dioxolane 
• 57529-04-1 2-chloro-1,3-dithiane 

Downstream Products

• 496043-83-5 2-[2'-(N-Boc-N-trimethylsilyl-amino)phenyl]-1,3-dithiane 
• 496043-95-9 methyl-[2-(2-oxo-2-phenyl-ethyl)-phenyl]-carbamic acid tert-butyl ester 
• 496043-67-5 2-[2'-(N-benzyl-N-Boc-amino)phenyl]-1,3-dithiane 
• 496043-69-7 2-[2'-(N-tert-butyloxycarbonyl-N-prenylamino)phenyl]-1,3-dithiane 
• 496043-70-0 2-[2'-(N-benzyloxycarbonylamino)phenyl]-1,3-dithiane 
• 496043-71-1 2-[2'-(N-methyloxycarbonylamino)phenyl]-1,3-dithiane 
• 396094-75-0 2-[2'-(N,N-di-tert-butoxycarbonylamino)phenyl]-1,3-dithiane 
• 396094-76-1 1-[2'-(N-Boc-N-methylamino)phenyl]-4-phenylbutan-2-one 
• 396094-78-3 2-[2'-(N-Boc-amino)phenyl]-1,3-dithiane 
• 396094-74-9 2-[2'-(N-Boc-N-methylamino)phenyl]-1,3-dithiane 
• 138343-89-2 tert-butyl 2-phenyl-1H-indole-1-carboxylate 
• 98598-96-0 tert-butyl 2-methyl-1H-indole-1-carboxylate 
• 27884-09-9 2-(4-methoxyphenyl)benzo[b]thiophene 
• 3558-24-5 1-methyl-2-phenyl-1H-indole 

Relevant articles and documents

A simple and convenient catalytic procedure for the preparation of dithioacetals

A simple procedure for the synthesis of cyclic and acyclic thioacetals from aldehydes is described which employs hydrogen chloride solutions generated from acetyl chloride and methanol. It was observed that the reaction could be carded out using catalytic quantities of acetyl chloride, potentially allowing acid sensitive substrates to be used under these conditions.

A 2 - substituted - 1, 3 - dithiane derivative of the preparation method

The invention provides a preparation method of a 2-substituted-1,3-dithiane derivative. The preparation method comprises the following steps: adding 1,3-dithiane (CAS:505-23-7) and 1,2-dichloroethane (DCE) or dichloromethane (DCM) into a reaction bottle, adding N-chlorosuccinimide (NCS) under ice-bath condition, and stirring for 0.5-1 h to prepare a 2-chloro-1,3-dithiane solution; and adding an aldehyde or ketone compound and a lewis acid catalyst into the above solution, and reacting to prepare the 2-substituted-1,3-dithiane derivative. By using the 1,3-dithiane solid and different types of aldehyde and keto-carbonyl compounds as raw material and using one or more of ferric trichloride, boron trifluoride diethyl etherate, methanesulfonic acid, aluminum trichloride, ferrous chloride and nickel chloride as catalysts, preparation of the 2-substituted-1,3-dithiane derivative is realized. The catalysts used in the invention are cheap and easily available, dosage of the catalysts is low and pollution of the catalysts is little. The solid raw materials used in the invention can avoid use of fetid toxic 1,3-dimercaptopropane with strong volatility, and the purpose of protecting an experimenter's body and reducing environmental pollution is realized. In addition, the preparation method has advantages of mild reaction condition, high yield, simple operation and the like.

Thioacetalization of aldehydes and ketones catalyzed by hexabromoacetone

Protection of p-anisaldehydewith 1,3-propanedithiol under UV irradiation without a catalyst resulted in 87% yield of 1,3-dithiane in 20 min. Addition of hexabromoacetone further reduced the reaction time and UV irradiation also accelerated the formation o