355382-21-7

Basic information

• Product Name: (4-METHOXY-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE
• Synonyms: TIMTEC-BB SBB007245;AKOS B023235;(4-METHOXY-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE;ART-CHEM-BB B023235
• CAS NO: 355382-21-7
• Molecular Formula: C₁₄H₁₆N₂O
• Molecular Weight: 228.29
• Mol File: 355382-21-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 369.3 °C at 760 mmHg
• Flash Point: 177.1 °C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 1.2E-05mmHg at 25°C
• CAS DataBase Reference: (4-METHOXY-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-METHOXY-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE(355382-21-7)
• EPA Substance Registry System: (4-METHOXY-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE(355382-21-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 355382-21-7(Hazardous Substances Data)

Usage

General Description

The chemical "(4-METHOXY-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE" is a compound that contains a methoxybenzyl group and a pyridine ring. It also contains an amine functional group, making it a derivative of both an aromatic benzyl compound and an amine. (4-METHOXY-BENZYL)-PYRIDIN-3-YLMETHYL-AMINE is likely to have applications in organic synthesis and medicinal chemistry, potentially being used as a building block for the synthesis of pharmaceuticals or other bioactive molecules. Its specific properties and potential uses would depend on further experimental and theoretical studies.

InChI:InChI=1/C14H16N2O/c1-17-14-6-4-12(5-7-14)9-16-11-13-3-2-8-15-10-13/h2-8,10,16H,9,11H2,1H3/p+1

Upstream product

• 3731-52-0 3-Aminomethylpyridine 
• 123-11-5 4-methoxy-benzaldehyde 
• 105482-70-0 C₁₄H₁₄N₂O 
• 3731-53-1 4-(aminomethyl)pyridine 
• 100-54-9 pyridine-3-carbonitrile 
• 2393-23-9 4-methoxy-benzylamine 

Relevant articles and documents

Ferrocene-Functionalized Dithiocarbamate Zinc(II) Complexes as Efficient Bifunctional Catalysts for the One-Pot Synthesis of Chromene and Imidazopyrimidine Derivatives via Knoevenagel Condensation Reaction

Four new mononuclear/coordination polymeric (CP) zinc(II) complexes (1-4) of ferrocenyl/pyridyl-functionalized dithiocarbamate ligands, N-ferrocenylmethyl-N-butyl dithiocarbamate (L1), N-ferrocenylmethyl-N-ethylmorpholine dithiocarbamate (L2), N-ferroceny

Synthesis and antitumor activity of novel pyridinium fullerene derivatives

Purpose: We have previously reported that some cationic fullerene derivatives exhibited anticancer activity, and they are expected to be a potential lead compound for an anti-drug resistant cancer agent. However, they are bis-adducts and a mixture of multiple regioisomers, which cannot be readily separated due to the variability of substituent positions on the fullerene cage. To overcome this issue, we evaluated the antiproliferative activities of a set of mono-adduct derivatives and examined their structure-activity relationship. In addition, the in vivo antitumor activity of selected derivatives was also examined. Methods: Nineteen pyridinium fullerene derivatives were newly designed and synthesized in this study. Their antiproliferative activities were evaluated using several cancer cell lines including drug-resistant cells. Furthermore, in vivo antitumor activity of several derivatives was investigated in mouse xenograft model of human lung cancer. Results: The derivatives inhibited the proliferation of cancer cell lines, including cisplatin-resistant cells and doxorubicin-resistant cells. It was also shown that compound 10 (10 μM), 13 (10 μM) and cis-14 (10 μM) induced the intracellular oxidative stress. In addition, compound 13 (20 mg/kg) and cis-14 (15 mg/kg) significantly exhibited antitumor activity in mouse xenograft model of human lung cancer. Conclusion: We synthesized a novel set of mono-adduct fullerene derivatives functionalized with pyridinium groups and found that most of them show potent antiproliferative activities against cancer cell lines and some of them show significant antitumor activities in vivo. We propose that these fullerene derivatives serve as the lead compounds for a novel type of antitumor agents.