35541-76-5

Basic information

• Product Name: 1,4-bis(iodomethyl)cyclohexane
• Synonyms: 1,4-Bis(iodomethyl)cyclohexane; cyclohexane, 1,4-bis(iodomethyl)-
• CAS NO: 35541-76-5
• Molecular Formula: C₈H₁₄I₂
• Molecular Weight: 364.0057
• Mol File: 35541-76-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 315.9°C at 760 mmHg
• Flash Point: 149.4°C
• Density: 1.954g/cm³
• Vapor Pressure: 0.000786mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 1,4-bis(iodomethyl)cyclohexane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-bis(iodomethyl)cyclohexane(35541-76-5)
• EPA Substance Registry System: 1,4-bis(iodomethyl)cyclohexane(35541-76-5)

Safety Data

• Hazardous Substances Data: 35541-76-5(Hazardous Substances Data)

Usage

Structure

Cyclohexane ring with two iodomethyl (-CH2I) groups attached at the 1 and 4 positions

Type

Derivative of cyclohexane

Use as a reagent

Organic synthesis, particularly in the preparation of other organic compounds containing iodomethyl groups

Application

Production of pharmaceuticals and agrochemicals

Role

Precursor in the manufacturing of various organic compounds

Significance

Crucial in the production of a wide range of organic materials and compounds

Upstream product

• 35541-78-7 cyclohexane-1,4-diyl bis(methylene) bis(4-methylbenzenesulfonate) 
• 105-08-8 bis-1,4-(hydroxymethyl)cyclohexane 

Downstream Products

• 3289-20-1 5,5'-cyclohexane-1,4-diyldimethylbissulfanyl-bis-[1,2,3,4]thiatriazole 
• 4982-20-1 1,4-dimethylidenecyclohexane 

Relevant articles and documents

BIS-DIAZENIUMDIOLATE COMPOUNDS AS ANTI-CANCER AGENTS

A series of double-component, bis O2-aryl diazeniumdiolate derivatives are provided, of which each molecule can release up to four nitric oxide molecules. These compounds show cytotoxic activities to cancer cells, such as human leukemia, breast cancer and lung cancer. Among them, the compound 3 showed the highest specific activity against human leukemia cells.

Pharmaceutically active compounds

The disclosed invention is compounds represented by the formula and pharmaceutically acceptable acid addition salts and quarternary amine salts thereof, wherein Z is phenyl, naphthyl or adamantyl; substituted phenyl wherein the substituents are one or more of halogen, lower alkoxy, phenoxy, nitrile, nitro, phenylsulfonyl, methylsulfonyl, isoxazol-2-yl, lower alkanoyl, benzoyl, lower alkoxycarbonyl, lower alkyl, loweralkylthio, phenyl, phenylaminothiocarbonyl, or lower alkylaminothiocarbonyl; 5 or 6 membered unsubstituted or substituted heterocyclic ring containing at least one nitrogen and one carbon in the ring, wherein the substituents are one or more of carboxyl, hydroxymethyl, loweralkyl, loweralkylcarbonyl or aryl lower alkyl; or tertiary butyl; X and Y are each independently a bond, -O-, STR1 Q is a divalent substituted or unsubstituted straight or branched chain lower alkanediyl, -lower alkanedinyl- cycloalkanediyl- lower alkanediyl-, lower alkendiyl, lower alkynediyl, phenylene, tetrahydrofurandiyl or tetrahydropyrandiyl; W is a monovalent substituted or unsubstituted aromatic heterocyclic single or fused ring containing from 5 to 10 ring atoms, at least one hetero atom of which is a nitrogen atom, wherein the substituents are hydroxy, amino, carbamoyl, carboxyl, nitrile, nitro, oxo, lower alkoxy carbonyl, halogen, sulfamyl, lower alkyl, lower alkylthio, lower alkoxy, hydroxyloweralkyl, lower alkoxycarbonylloweralkyl, amino loweralkyl, carboxyloweralkyl, guanidino, thioureido, lower alkylsulfonylamino, aminocarbonylloweralkyl, allyloxycarbonylmethyl or carbamoyloxylowralkyl; and W' is divalent W. The compounds have antiviral activity, antiinflammatory activity and are PAF inhibitors.