3558-61-0

Basic information

• Product Name: METHOXY-PHENYL-ACETIC ACID METHYL ESTER
• Synonyms: METHOXY-PHENYL-ACETIC ACID METHYL ESTER;2-Methoxy-2-phenylacetic acid methyl ester;methyl 2-methoxy-2-phenylacetate;(S)-methyl 2-methoxy-2-phenylacetate
• CAS NO: 3558-61-0
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.20048
• Mol File: 3558-61-0.mol
• Article Data: 58

Chemical Properties

• Boiling Point: 258 °C at 760 mmHg
• Flash Point: 88.3 °C
• Appearance: /
• Density: 1.086 g/cm³
• Vapor Pressure: 0.014mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: METHOXY-PHENYL-ACETIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: METHOXY-PHENYL-ACETIC ACID METHYL ESTER(3558-61-0)
• EPA Substance Registry System: METHOXY-PHENYL-ACETIC ACID METHYL ESTER(3558-61-0)

Safety Data

• Hazardous Substances Data: 3558-61-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 47, p. 5404, 1982 DOI: 10.1021/jo00148a038Tetrahedron Letters, 22, p. 2747, 1981 DOI: 10.1016/S0040-4039(01)90541-6

InChI:InChI=1/C10H12O3/c1-12-9(10(11)13-2)8-6-4-3-5-7-8/h3-7,9H,1-2H3/t9-/m1/s1

Upstream product

• 67-56-1 methanol 
• 7021-09-2 rac-methoxyphenylacetic acid 
• 113556-18-6 dimethyl α-bromo-α-phenylmalonate 
• 124-41-4 sodium methylate 
• 611-71-2 MANDELIC ACID 
• 74-88-4 methyl iodide 
• 2912-62-1 α-chlorophenylacetyl chloride 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 13157-96-5 methyl 2-chloro-2-methoxyacetate 
• 71-43-2 benzene 
• 31528-95-7 1-(1-naphthyl)-3-phenyl-2,2-dichloroaziridine 
• 5467-21-0 methyl 2,2,2-triphenylacetate 
• 83831-70-3 ((E)-2-Methanesulfinyl-2-methanesulfonyl-vinyl)-benzene 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 

Downstream Products

• 7476-63-3 (+/-)-2-methoxy-2-phenylacetamide 
• 26164-26-1 (S)-2-methoxy-2-phenylacetic acid 
• 7476-62-2 (β-oxy-α-methoxy-isobutyl)-benzene 
• 7476-64-4 3-(α-methoxy-benzyl)-pentan-3-ol 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 2979-22-8 2-methoxy-2-phenylethanol 
• 7021-09-2 rac-methoxyphenylacetic acid 
• 82656-33-5 4,5-Dimethoxy-5-(methoxy-phenyl-methyl)-5H-furan-2-one 
• 93-58-3 benzoic acid methyl ester 
• 19190-53-5 2-methoxy-2-phenylacetaldehyde 
• 121129-32-6 (+/-)-O-Methylmandelohydroxamic acid 
• 65-85-0 benzoic acid 
• 101-41-7 benzeneacetic acid methyl ester 
• 642479-31-0 (1R,2S)-1-(6-Bromo-pyridin-2-yl)-2-methoxy-2-phenyl-ethanol 

Relevant articles and documents

Three-component reaction of aryl diazoacetates, alcohols, and aldehydes (or imines): Evidence of alcoholic oxonium ylide intermediates

(Chemical Equation Presented) The Rh(II)-catalyzed three-component reaction of aryl diazoacetates, alcohols and aldehydes was explored, which provided evidence of alcoholic oxonium ylide formation for O-H insertion. A new C-C bond formation reaction where alcoholic oxonium ylides were trapped by electron-deficient aryl aldehydes (or imines) was realized.

N-SUBSTITUTED ALPHA-AMINO AND ALPHA-HYDROXY CARBOXAMIDE DERIVATIVES

Disclosed are N-substituted α-amino and α-hydroxy carboxamides, pharmaceutical compositions comprising them, and methods of using them.

Bis(imino)pyridine iron complexes for catalytic carbene transfer reactions

The bis(imino)pyridine iron complex, for the first time, is developed as an effective metal carbene catalyst for carbene transfer reactions of donor-acceptor diazo compounds. Its broad catalytic capability is demonstrated by a range of metal carbene reactions, from cyclopropanation, cyclopropenation, epoxidation, and Doyle-Kirmse reaction to O-H insertion, N-H insertion, and C-H insertion reactions. The asymmetric cyclopropanation of styrene and methyl phenyldiazoacetate was successfully achieved by the new chiral bis(imino)pyridine iron catalyst, which delivers a new gateway for the development of chiral iron catalysis for metal carbene reactions.