35588-53-5

Basic information

• Product Name: [4-(METHYLTHIO)PHENYL]HYDRAZINE HYDROCHLORIDE
• Synonyms: (4-METHYLSULFANYLPHENYL)HYDRAZINE HYDROCHLORIDE;[4-(METHYLTHIO)PHENYL]HYDRAZINE HYDROCHLORIDE;1-(4-(Methylthio)phenyl)hydrazine hydrochloride;4-Hydrazinothioanisole hydrochloride, 4-Hydrazinophenyl methyl sulphide hydrochloride;4-(Methylsulphanyl)phenylhydrazinehydrochloride
• CAS NO: 35588-53-5
• Molecular Formula: C7H11ClN2S
• Molecular Weight: 190.69
• Mol File: 35588-53-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 197(dec.)
• Boiling Point: 305.7°Cat760mmHg
• Flash Point: 138.7°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.000806mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: [4-(METHYLTHIO)PHENYL]HYDRAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(METHYLTHIO)PHENYL]HYDRAZINE HYDROCHLORIDE(35588-53-5)
• EPA Substance Registry System: [4-(METHYLTHIO)PHENYL]HYDRAZINE HYDROCHLORIDE(35588-53-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 35588-53-5(Hazardous Substances Data)

Usage

General Description

[4-(METHYLTHIO)PHENYL]HYDRAZINE HYDROCHLORIDE is a chemical compound that is used in the synthesis of various organic compounds. It is a hydrazine derivative, which means it contains a nitrogen-nitrogen double bond. [4-(METHYLTHIO)PHENYL]HYDRAZINE HYDROCHLORIDE is commonly used in pharmaceutical research and drug discovery due to its potential biological activities. It has also been studied for its potential use as an antitumor and antiviral agent. Additionally, it is used as a reagent in organic chemical reactions, particularly in the formation of carbon-nitrogen bonds. [4-(METHYLTHIO)PHENYL]HYDRAZINE HYDROCHLORIDE is stable under normal conditions, but should be handled with care due to its potential toxicity and reactivity.

InChI:InChI=1/C7H10N2S/c1-10-7-4-2-6(9-8)3-5-7/h2-5,9H,8H2,1H3

Upstream product

• 115171-09-0 N,N'-bis-(t-butoxycarbonyl)-4-(methylthio)phenylhydrazine 
• 104-96-1 4-methylsulfanylaniline 
• 18620-04-7 4-thioanisolemagnesium bromide 
• 104-95-0 (4-bromophenyl)thioanisole 

Downstream Products

• 1383843-39-7 1,3-bis(4-chlorobenzyl)-2-methyl-5-(methylthio)-1H-indole 
• 96868-66-5 2-(2-(1-benzyl-2-methyl-5-(methylthio)-1H-indol-3-yl)ethyl)isoindoline-1,3-dione 
• 96869-27-1 2-(2-(1-(3,4-dichlorobenzyl)-2-methyl-5-(methylthio)-1H-indol-3-yl)ethyl)isoindoline-1,3-dione 
• 847233-91-4 3-(4-chlorophenoxy)-2-methyl-5-(methylthio)-1H-indole-1-acetic acid methyl ester 
• 847233-92-5 3-(4-chlorophenoxy)-2-methyl-5-(methylsulfonyl)-1H-indole-1-acetic acid methyl ester 

Relevant articles and documents

Synthesis of Aryl Hydrazines via CuI/BMPO Catalyzed Cross-Coupling of Aryl Halides with Hydrazine Hydrate in Water

The N,N’-bis(2,6-dimethylphenyl)oxalamide was discovered as a powerful ligand for Cu-catalyzed cross-coupling of aryl halides with hydrazine hydrate, leading to the formation of a variety of aryl hydrazines at 80 oC in water under the assistance of K3PO4 and 4 mol% cetyltrimethylammonium bromide from aryl bromides and aryl iodides. Good to excellent yields were observed in most cases.

CYP2C9 structure-metabolism relationships: Optimizing the metabolic stability of COX-2 inhibitors

The cytochrome P450 (CYP) family is composed of a large group of monooxygenases that mediate the metabolism of xenobiotics and endogenous compounds. CYP2C9, one of the major isoforms of the CYP family, is responsible for the phase I metabolism of a variety of drugs. The aim of the present investigation is to use rational design together with MetaSite, a metabolism site prediction program, to synthesize compounds that retain their pharmacological effects but that are metabolically more stable in the presence of CYP2C9. The model compound for the study is the nonsteroidal anti-inflammatory drug celecoxib, a COX-2 selective inhibitor and known CYP2C9 substrate. Thirteen analogs of celecoxib were designed, synthesized, and evaluated with regard to their metabolic properties and pharmacologic effects. The docking solutions and the predictions from MetaSite gave useful information leading to the design of new compounds with improved metabolic properties.

3-hetero-substituted-N-benzyl-indoles

Compounds having the formula: are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labour, spontaneous abortion, dysmenorrhea, and migraine.