35600-62-5

Basic information

• Product Name: methyl N-(chloromethyl)-N-phenyl-carbamate
• Synonyms: methyl N-(chloromethyl)-N-phenyl-carbamate
• CAS NO: 35600-62-5
• Molecular Weight: 199.637
• Mol File: 35600-62-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl N-(chloromethyl)-N-phenyl-carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl N-(chloromethyl)-N-phenyl-carbamate(35600-62-5)
• EPA Substance Registry System: methyl N-(chloromethyl)-N-phenyl-carbamate(35600-62-5)

Safety Data

• Hazardous Substances Data: 35600-62-5(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 50-00-0 formaldehyd 
• 2603-10-3 N-phenyl methyl carbamate 

Downstream Products

• 40151-44-8 (4-Chloro-phenylsulfanylmethyl)-phenyl-carbamic acid methyl ester 
• 900187-57-7 (4-nitro-phenoxymethyl)-phenyl-carbamic acid methyl ester 
• 40151-07-3 Butoxymethyl-phenyl-carbamic acid methyl ester 
• 40151-42-6 (2,4-Dichloro-phenoxymethyl)-phenyl-carbamic acid methyl ester 
• 40151-06-2 Methyl-N-isopropoxymethyl-N-phenyl carbamate 
• 40151-03-9 (4-Chloro-benzenesulfonylmethyl)-phenyl-carbamic acid methyl ester 
• 50887-78-0 Dithiopropionic acid (methoxycarbonyl-phenyl-amino)-methyl ester 
• 40151-01-7 Dithiocarbonic acid O-ethyl ester S-[(methoxycarbonyl-phenyl-amino)-methyl] ester 
• 40151-48-2 [N-(2,4-Dichloro-phenyl)aminooxymethyl]-phenyl-carbamic acid methyl ester 
• 40151-43-7 Butylsulfanylmethyl-phenyl-carbamic acid methyl ester 
• 40151-05-1 Methyl-N-ethoxymethyl-N-phenyl carbamate 
• 40151-04-0 Methyl-N-methoxymethyl-N-phenyl carbamate 

Relevant articles and documents

CANNABINOID DERIVATIVES

This disclosure relates generally to cannabinoid derivatives, pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives.

Synthesis, hydrolyses and dermal delivery of N-alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) derivatives of phenol, imide and thiol containing drugs

Synthesis, characterization and hydrolysis in aqueous buffers of novel N-alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) derivatives of substituted phenols, theophylline (Th) and 6-mercaptopurine (6MP) were carried out. The mechanism of hydrolysis was further investigated by synthesis, characterization and hydrolysis of N-aryl-N-alkyloxycarbonylaminomethyl (NArNAOCAM) derivatives of phenols. The hydrolysis follows pseudounimolecular first order kinetics and operates by way of an SN1-type mechanism. Topical delivery of selected derivatives of acetaminophen (APAP), Th and 6MP was examined in in vitro diffusion cell experiments from IPM across hairless mice skins. The prodrug of APAP and 6MP increased permeation across the skin by about 2- and 4-fold, respectively, compared to the parent drug. NANAOCAM promoieties can act as novel prodrug derivatives of phenol, imide and thiol containing drugs for enhancing topical absorption.