3561-68-0

Basic information

• Product Name: 1,3,3-tris(benzenesulfonyl)propylsulfonylbenzene
• CAS NO: 3561-68-0
• Molecular Formula: C₂₇H₂₄O₈S₄
• Molecular Weight: 604.747
• Mol File: 3561-68-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 916°Cat760mmHg
• Flash Point: 600.3°C
• Density: 1.427g/cm³
• CAS DataBase Reference: 1,3,3-tris(benzenesulfonyl)propylsulfonylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,3-tris(benzenesulfonyl)propylsulfonylbenzene(3561-68-0)
• EPA Substance Registry System: 1,3,3-tris(benzenesulfonyl)propylsulfonylbenzene(3561-68-0)

Safety Data

• Hazardous Substances Data: 3561-68-0(Hazardous Substances Data)

Usage

Abbreviation

TPPSB

Chemical class

Sulfone

Molecular weight

584.68 g/mol

Physical state

White to yellow solid

Solubility

Soluble in organic solvents such as ethanol and chloroform

Applications

a. Crosslinking agent in polymer chemistry
b. Coupling reagent in organic synthesis
c. Potential applications in organic electronics

Biological activity

Investigated for anti-cancer properties

Cancer cell inhibition

Shown to inhibit the growth of cancer cells in laboratory experiments

Further research

Needed to fully understand its potential therapeutic applications

Upstream product

• 110-89-4 piperidine 
• 39082-53-6 1,1-bis(phenylsulfonyl)ethylene 
• 110-91-8 morpholine 
• 3406-02-8 bis(phenylsulfonyl)methane 
• 110-58-7 n-Pentylamine 
• 109-89-7 diethylamine 
• 124-30-1 1-aminooctadecane 
• 100-46-9 benzylamine 
• 3561-67-9 bis(phenylthio)methane 
• 590-86-3 isovaleraldehyde 
• 108-94-1 cyclohexanone 
• 108-98-5 thiophenol 
• 2394-07-2 1,1-bis(phenylsulphonyl)methyl methyl sulphone 
• 75-09-2 dichloromethane 

Relevant articles and documents

Enantioselective organocatalytic conjugate addition of aldehydes to vinyl sulfones and vinyl phosphonates as challenging michael acceptors

Chiral amines with a pyrrolidine framework catalyze the enantioselective conjugate addition of a broad range of aldehydes to various vinyl sulfones and vinyl phosphonates in high yields and with enantioselectivities up to >99% ee. This novel process provides synthetically useful chiral γ-gem-sulfonyl or phosphonyl aldehydes which can be widely functionalized with retention of the enantiomeric excess. Mechanistic insights including DFT calculations are explored in detail.

THE REACTION BETWEEN PHENYLIODONIUM BIS(PHENYLSULFONYL)METHANIDE AND PYRROLIDINE

The main product from the title reaction is the enamine N--pyrrolidine, 4.Tetrakis(phenylsulfonyl)propane, 3, is a by-product, when dichloromethane is used; it is formed independently from this solvent and bis(phenylsulfonyl)methane in the presence of pyrrolidine.Key words: Phenyliodonium bis(phenylsulfonyl)methanide, N--pyrrolidine, 1,1,3,3-tetrakis(phenylsulfonyl)propane, dichloromethane, pyrrolidine.

REACTIONS OF 1,1-BIS(ARYLSULFONYL)ETHENES WITH NUCLEOPHILIC AND ELECTROPHILIC REAGENTS

The reaction of 1,1-bis(arylsulfonyl)ethenes with nucleophilic reagents (aromatic and heterocyclic thiols, sulfinic acids) leads to the formation of 1,1-bis(arylsulfonyl)-2-aryl(heteryl)-thio(sulfonyl)ethanes.The anions of CH acids (nitromethane, aromatic