35638-83-6

Basic information

• Product Name: (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-4-(benzyloxy)-5-(hydroxymethyl) tetrahydrofuran-3-ol
• CAS NO: 35638-83-6
• Molecular Weight: 357.369
• Mol File: 35638-83-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-4-(benzyloxy)-5-(hydroxymethyl) tetrahydrofuran-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-4-(benzyloxy)-5-(hydroxymethyl) tetrahydrofuran-3-ol(35638-83-6)
• EPA Substance Registry System: (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-4-(benzyloxy)-5-(hydroxymethyl) tetrahydrofuran-3-ol(35638-83-6)

Safety Data

• Hazardous Substances Data: 35638-83-6(Hazardous Substances Data)

Upstream product

• 58-61-7 adenosine 
• 100-46-9 benzylamine 
• 1576-37-0 N-benzyl-p-toluenesulfonamide 
• 33528-13-1 N-nitroso-N-benzyl-p-toluenesulphonamide 
• 17331-15-6 (E)-N'-(9-((2S,3R,4S,5R)3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)-N,N-dimethylformimidamide 
• 908094-04-2 phenyldiazomethane 

Relevant articles and documents

Structure-guided design of a methyl donor cofactor that controls a viral histone H3 lysine 27 methyltransferase activity

vSET (a viral SET domain protein) is an attractive polycomb repressive complex 2 (PRC2) surrogate to study the effect of histone H3 lysine 27 (H3K27) methylation on gene transcription, as both catalyze histone H3K27 trimethylation. To control the enzymatic activity of vSET in vivo with an engineered S-adenosyl-l-methionine (SAM) analogue as methyl donor cofactor, we have carried out structure-guided design, synthesis, and characterization of orthogonal vSET methyltransferase mutant/SAM analogue pairs using a "bump-and-hole" strategy.

Nucleosides. VI. Synthesis of 2'-O-, 3'-O- and 5'-O-benzyladenosine

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