3567-00-8 Usage
Description
Rubrofusarin is a benzochromenone compound, specifically a benzo[g]chromen-4-one derivative, featuring two hydroxy substituents at positions 5 and 6, as well as a methyl and methoxy substituent at positions 2 and 8, respectively. It is an orange polyketide pigment that serves as a common intermediate in various fungal biosynthetic pathways.
Uses
Used in Pharmaceutical Applications:
Rubrofusarin is used as a therapeutic agent for treating chronic restraint stress-induced depressive symptoms. Its application in this context is attributed to its potential neuroprotective and mood-enhancing properties, which can help alleviate the symptoms associated with stress and depression.
Used in Fungal Biosynthesis:
Rubrofusarin plays a significant role as an intermediate in the biosynthesis of various compounds in different fungal species. This makes it an essential component in the study and understanding of fungal metabolic pathways and the development of novel bioactive compounds derived from fungi.
Biochem/physiol Actions
Rubrofusarin is an orange polyketide pigment produced by Fusarium graminearum and other fungal species that exhibit potent anti-cancer and anti-mycobacterial activities. Rubrofusarin is a mycotoxin that inhibits human DNA topoisomerase II-α.. Additionally, Rubrofusarin shows a significant anti-estrogenic activity.
Check Digit Verification of cas no
The CAS Registry Mumber 3567-00-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,5,6 and 7 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 3567-00:
(6*3)+(5*5)+(4*6)+(3*7)+(2*0)+(1*0)=88
88 % 10 = 8
So 3567-00-8 is a valid CAS Registry Number.
InChI:InChI=1/C15H12O5/c1-7-3-10(16)14-12(20-7)5-8-4-9(19-2)6-11(17)13(8)15(14)18/h3-6,17-18H,1-2H3
3567-00-8Relevant articles and documents
-
Baker,P.M.,Roberts,J.C.
, p. 2234 - 2237 (1966)
-
Biomimetic Syntheses of the Polyketide Fungal Metabolites Alternariol and Rubrofusarin: Models for Cyclisation Reactions Catalysed by Polyketide Synthase Enzymes
Abell, Chris,Bush, Brian D.,Staunton, James
, p. 15 - 17 (2007/10/02)
Various phenolic polyketone derivatives containing thioester groups, closely analogous in structure to proposed thioester intermediates bound to polyketide synthase enzymes, undergo highly regioselective biomimetic cyclisations to form one or the other of the heptaketide metabolites, rubrofusarin and alternariol methyl ether.