356773-26-7

Basic information

• Product Name: 4-[(3-phenyl-tioureido)methyl]benzoic acid
• Synonyms: 4-[(3-phenyl-tioureido)methyl]benzoic acid
• CAS NO: 356773-26-7
• Molecular Weight: 286.354
• Mol File: 356773-26-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[(3-phenyl-tioureido)methyl]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(3-phenyl-tioureido)methyl]benzoic acid(356773-26-7)
• EPA Substance Registry System: 4-[(3-phenyl-tioureido)methyl]benzoic acid(356773-26-7)

Safety Data

• Hazardous Substances Data: 356773-26-7(Hazardous Substances Data)

Upstream product

• 56-91-7 p-aminomethylbenzoic acid 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 643004-97-1 4-[(4-oxo-2-(phenylimino)thiazolidin-3-yl)methyl]benzoic acid 
• 1148126-97-9 4-[(5-naphthalen-1-ylmethylene-4-oxo-2-(phenylimino)thiazolidin-3-yl)methyl]benzoic acid 
• 1148127-00-7 4-([5-(4-hydroxybenzylidene)-4-oxo-2-(phenylimino)thiazolidin-3-yl]methyl)benzoic acid 
• 1148126-93-5 4-([4-oxo-5-(4-phenoxybenzylidene)-2-(phenylimino)thiazolidin-3-yl]methyl)benzoic acid 

Relevant articles and documents

5-Arylidene-4-thiazolidinone derivatives active as antidegenerative agents on human chondrocyte cultures

5-Arylidene-2-oxo-4-thiazolidinones and 2-phenylimino analogues were evaluated for their antidegenerative activity on human chondrocyte cultures stimulated by IL-1β and for their inhibitory capability against matrix metalloproteinase- 13. Our results indicated that 5-arylidene-4-thiazolidinone derivatives 1-9 exhibit antidegenerative activity and could block multiple cartilage destruction during the osteoarthritic process. Out of the selected compounds, (5-arylidene- 2,4-dioxothiazolidin-3-yl)acetic acids 7-9 showed significant effectiveness in reducing NO release and restoring normal levels of GAGs in chondrocytes treated with IL-1β. Moreover, benzoic acids 1, 5 and 6 proved to be effective MMP-13 inhibitors and were able to restore normal levels of GAGs.