356793-34-5Relevant articles and documents
A new procedure for the enantioselective vinylogous aldol reaction of Chan's diene
Villano, Rosaria,Acocella, Maria Rosaria,Massa, Antonio,Palombi, Laura,Scettri, Arrigo
, p. 3332 - 3334 (2007/10/03)
Chiral δ-hydroxy-β-ketoesters are easily available through the enantioselective vinylogous aldol reaction of Chan's diene promoted by a SiCl4/chiral phosphoramide catalytic system. The procedure is conveniently exploited for a very rapid approach to (+)-kavain, a natural bio-active α-pyrone compound.