357166-30-4 Usage
Description
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hydrate, also known as Pemetrexed Disodium Hydrate, is a chemotherapy drug with a complex chemical structure. It is characterized by its ability to inhibit key enzymes involved in the synthesis of nucleotides, which are essential for the replication and survival of cancer cells.
Uses
Used in Oncology:
Pemetrexed Disodium Hydrate is used as a chemotherapy agent for the treatment of pleural mesothelioma and non-small cell lung cancer. It works by inhibiting thymidylate synthase, a key enzyme in the synthesis of thymidine, a nucleotide necessary for DNA replication. Additionally, it exhibits inhibitory activities towards other folate-dependent enzymes, further disrupting the biosynthesis of nucleotides and impeding cancer cell proliferation.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Pemetrexed Disodium Hydrate is utilized as an active pharmaceutical ingredient in the formulation of cancer treatment drugs. Its development and production involve complex chemical synthesis and purification processes to ensure the drug's efficacy and safety for patients.
Used in Research and Development:
Pemetrexed Disodium Hydrate is also used in research and development for the study of its mechanism of action, potential synergistic effects with other drugs, and the development of new therapeutic strategies for cancer treatment. Researchers investigate its interactions with various biological targets and its potential to overcome drug resistance in cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 357166-30-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,7,1,6 and 6 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 357166-30:
(8*3)+(7*5)+(6*7)+(5*1)+(4*6)+(3*6)+(2*3)+(1*0)=154
154 % 10 = 4
So 357166-30-4 is a valid CAS Registry Number.
InChI:InChI=1/C20H21N5O6.2Na.H2O/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;;1H2/q;2*+1;/p-2/t13-;;;/m0.../s1