357204-44-5

Basic information

• Product Name: C₇H₆ClN₃OS
• Synonyms: C₇H₆ClN₃OS
• CAS NO: 357204-44-5
• Molecular Weight: 215.663
• Mol File: 357204-44-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₇H₆ClN₃OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₇H₆ClN₃OS(357204-44-5)
• EPA Substance Registry System: C₇H₆ClN₃OS(357204-44-5)

Safety Data

• Hazardous Substances Data: 357204-44-5(Hazardous Substances Data)

Upstream product

• 27006-76-4 5-chloro-4-formyl-1,3-dimethylpyrazole 

Downstream Products

• 1392131-56-4 1-(2-fluorophenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-57-5 1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-62-2 1-(4-(trifluoromethylthio)phenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-54-2 1-(4-bromo-2-(trifluoromethyl)phenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-53-1 1-(2-bromo-4,6-difluorophenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-52-0 1-(2-bromo-5-fluorophenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-61-1 1-(5-chloro-2-fluorophenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-60-0 1-(3-fluorophenethyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-55-3 1-(2-fluorobenzyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-59-7 1-(2-fluorophenethyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-58-6 1-(2-fluoro-3-(trifluoromethyl)phenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea 

Relevant articles and documents

Synthesis and bioactivity of pyrazole acyl thiourea derivatives

Sixteen novel pyrazole acyl thiourea derivatives 6 were synthesized from monomethylhydrazine (phenylhydrazine) and ethyl acetoacetate. The key 5-chloro-3- methyl-1-substituted-1H-pyrazole-4-carbonyl chloride intermediates 4 were first generated in four steps through cyclization, formylation, oxidation and acylation. Thess were then reacted with ammonium thiocyanate in the presence of PEG-400 to afford 5-chloro-3- methyl -1-substituted-1H-pyrazole-4-carbonyl isothiocyanates 5. Subsequent reaction with fluorinated aromatic amines resulted in the formation of the title compounds. The synthesized compound were unequivocally characterized by IR, 1H-NMR, 13C-NMR and elemental analysis and some of the synthesized compounds displayed good antifungal activities against Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica and anti-TMV activity in preliminary antifungal activity tests.