35737-59-8Relevant articles and documents
5,5-Disubstituted Hydantoins: Syntheses and Anti-HIV Activity
Comber, Robert N.,Reynolds, Robert C.,Friedrich, Joyce D.,Manguikian, Roupen A.,Buckheit, Robert W.,et al.
, p. 3567 - 3572 (2007/10/02)
A series of 5,5-disubstituted hydantoin derivatives was synthesized by alkylating 5,5-bis(mercaptomethyl)-2,4-imidazolidinedione (3) with various halomethylaromatic or halomethylheteroaromatic precursors, or by using the Buchener-Berg procedure on the required ketone.When evaluated for their ability to inhibit HIV-induced cell killing and virus production in CEM or MT-2 cells only compounds 2, 4n, 4o, and 4i demonstrated modest activity, the latter with an IC50 = 53 μM
Nitrogen- and sulfur-containing models for metallo-enzymes. Part I. Synthesis and physical studies of 2(2-pyridyl)-1,3-dithioalkyl-2-propanols, 2(2-pyridyl)- and 2(2-imidazolyl)-1,3-dimercapto-2-propanols
Curtis, N. J.,Brown, R. S.
, p. 65 - 75 (2007/10/02)
Several compounds of the title class have been synthesized as small-molecule analogues for the metal-binding sites in such biochemical systems as ADH.The ligands containing pyridine and two thioethers do not bind divalent metals Co(2+), Zn(2+), Cu(2+), N
