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357424-21-6

357424-21-6

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357424-21-6 Usage

Chemical Properties

Pale Yellow Solid

Uses

Different sources of media describe the Uses of 357424-21-6 differently. You can refer to the following data:
1. A metabolite of Varenicline. Metabolite M3b.
2. A metabolite of Varenicline. Metabolite M3b

Check Digit Verification of cas no

The CAS Registry Mumber 357424-21-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,7,4,2 and 4 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 357424-21:
(8*3)+(7*5)+(6*7)+(5*4)+(4*2)+(3*4)+(2*2)+(1*1)=146
146 % 10 = 6
So 357424-21-6 is a valid CAS Registry Number.

357424-21-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Hydroxy Varenicline

1.2 Other means of identification

Product number -
Other names 1,6,7,8,9,10-Hexahydro-6,10-methano-2H-pyrazino[2,3-h][3]benzazepin-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:357424-21-6 SDS

357424-21-6Upstream product

357424-21-6Downstream Products

357424-21-6Relevant articles and documents

3,5-Bicyclic aryl piperidines: A novel class of α4β2 neuronal nicotinic receptor partial agonists for smoking cessation

Coe, Jotham W.,Brooks, Paige R.,Wirtz, Michael C.,Bashore, Crystal G.,Bianco, Krista E.,Vetelino, Michael G.,Arnold, Eric P.,Lebel, Lorraine A.,Fox, Carol B.,Tingley III, F. David,Schulz, David W.,Davis, Thomas I.,Sands, Steven B.,Mansbach, Robert S.,Rollema, Hans,O'Neill, Brian T.

, p. 4889 - 4897 (2008/12/23)

3,5-Bicyclic aryl piperidines are a new class of high-affinity α4β2 nicotinic receptor agents. We have sought nicotinic receptor partial agonists of the α4β2 nicotinic acetylcholine receptor for smoking cessation, and a number of compounds fulfill potency, selectivity, and efficacy requirements in vitro. In vivo, selected agents demonstrate potent partial agonist efficacy on the mesolimbic dopamine system, a key measure of therapeutic potential for smoking cessation.

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