357429-20-0

Basic information

• Product Name: N-{N-[(2S)-1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carbonyl]-L-(benzyl)histidyl}-L-proline benzyl ester
• Synonyms: N-{N-[(2S)-1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carbonyl]-L-(benzyl)histidyl}-L-proline benzyl ester
• CAS NO: 357429-20-0
• Molecular Weight: 643.858
• Mol File: 357429-20-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-{N-[(2S)-1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carbonyl]-L-(benzyl)histidyl}-L-proline benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-{N-[(2S)-1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carbonyl]-L-(benzyl)histidyl}-L-proline benzyl ester(357429-20-0)
• EPA Substance Registry System: N-{N-[(2S)-1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carbonyl]-L-(benzyl)histidyl}-L-proline benzyl ester(357429-20-0)

Safety Data

• Hazardous Substances Data: 357429-20-0(Hazardous Substances Data)

Upstream product

• 82938-50-9 (4S)-N-tert-butyldimethylsilylazetidin-2-one-4-carboxylic acid 
• 33477-33-7 N-Boc-L-(benzyl)histidyl-L-proline benzyl ester 
• 21761-38-6 N-(1-benzyl-N^α-tert-butoxycarbonyl-histidyloxy)-succinimide 
• 20898-44-6 Boc-His(Bzl)-OH 
• 357429-08-4 (S)-(2,5-dioxopyrrolidin-1-yl) 1-(tert-butyldimethylsilyl)-4-oxoazetidine-2-carboxylate 

Downstream Products

• 357429-21-1 N-{N-[(2S)-4-oxoazetidine-2-carbonyl]-L-(benzyl)histidyl}-L-proline benzyl ester 

Relevant articles and documents

β-lactam derivatives as enzyme inhibitors: Carboxy peptidyl derivatives of (S)-4-Oxoazetidine-2-carboxylate as peptidomimetics

4-Oxoazetidine-2-carboxylic acid, protected at the nitrogen by silyl groups, was coupled with amino acid and oligopeptide esters. Desilylation and deprotection of the amino acid residues yielded the free β-lactam peptides. Structure and properties were elucidated by spectroscopic methods and discussed. Some selected compounds Were tested as fibrinogen inhibitors and for thrombocyte aggregation. None of the compounds showed any activity up to a concentration of 10-5 Mol/1. Some other compounds exhibited a weak inhibitory activity against elastase (PPE).