35761-27-4

Basic information

• Product Name: METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE
• Synonyms: METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE;METHYL 2-(S)-[N-(BENZYLOXY)CARBONYL]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE;3-Amino-N-[(phenylmethoxy)carbonyl]-L-alanine methyl ester;Methyl 2-(S)-[N-Carbobenzyloxy]amino-3-aminopropionate;3-AMino-N-[(phenylMethoxy)carbonyl]-L-alanine Methyl Ester Hydrochloride;Z-Dap-OMe.HCl;Z-L-Dap-OMe*HCl;Nα-Z-L-2,3-diaminopropionic acid methyl ester hydrochloride≥ 98.5% (HPLC)
• CAS NO: 35761-27-4
• Molecular Formula: C₁₂H₁₆N₂O₄*ClH
• Molecular Weight: 288.73
• Product Categories: Amino Acids & Derivatives;amino acids
• Mol File: 35761-27-4.mol
• Article Data: 25

Chemical Properties

• Melting Point: 157-162°C dec.
• Boiling Point: 423.692oC at 760 mmHg
• Flash Point: 210.042oC
• Appearance: /
• Density: 1.212g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE(35761-27-4)
• EPA Substance Registry System: METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE(35761-27-4)

Safety Data

• Hazardous Substances Data: 35761-27-4(Hazardous Substances Data)

Usage

Description

METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE is a chemical compound that serves as an important building block for the synthesis of peptides containing diaminopimelic acid (DAP) residues. It is a key component in the production of various bioactive peptides, such as bleomycins, edeines, and tuberactinomycins, which have significant applications in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE is used as a key building block for the synthesis of bioactive peptides containing DAP residues. Its role in the production of peptides such as bleomycins, edeines, and tuberactinomycins makes it a valuable component in the development of pharmaceuticals with potential therapeutic applications.
Used in Peptide Synthesis:
METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE is used as a crucial intermediate in the synthesis of peptides with DAP residues. Its presence in the synthesis process allows for the creation of complex peptide structures that can be further utilized in various applications, including drug development and research.
Used in Research and Development:
METHYL 2-(S)-[N-CARBOBENZYLOXY]AMINO-3-AMINOPROPIONATE, HYDROCHLORIDE is used as a research tool for studying the properties and potential applications of peptides containing DAP residues. Its role in the synthesis of bioactive peptides makes it an essential component in the ongoing research and development efforts aimed at discovering new therapeutic agents and understanding their mechanisms of action.

InChI:InChI=1/C12H16N2O4/c1-17-11(15)10(7-13)14-12(16)18-8-9-5-3-2-4-6-9/h2-6,10H,7-8,13H2,1H3,(H,14,16)/t10-/m0/s1

Upstream product

• 67-56-1 methanol 
• 35761-26-3 (S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoic acid 
• 1676-81-9 N-benzyloxycarbonyl-L-serine methyl ester 
• 2304-96-3 N-benzyloxycarbonyl-L-asparagine 
• 501-53-1 benzyl chloroformate 
• 90035-60-2 (L)-N-Z-azidoalanine methyl ester 
• 58457-98-0 methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-[(tert-butoxycarbonyl)amino]propanoate 
• 75760-11-1 (S)-methyl 3-amino-2-(((benzyloxy)carbonyl)amino)propanoate 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 58457-98-0 methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-[(tert-butoxycarbonyl)amino]propanoate 
• 169605-01-0 (S)-2-Benzyloxycarbonylamino-3-(3-chloromethyl-benzoylamino)-propionic acid methyl ester 
• 211756-24-0 (S)-2-Benzyloxycarbonylamino-3-formylamino-propionic acid methyl ester 
• 211756-18-2 (S)-3-(2-Aza-bicyclo[2.2.1]hept-5-en-2-yl)-2-benzyloxycarbonylamino-propionic acid methyl ester 
• 130106-15-9 (S)-2-Benzyloxycarbonylamino-3-(4-chloro-butyrylamino)-propionic acid methyl ester 
• 211756-63-7 (S)-2-Benzyloxycarbonylamino-3-(3,3-dimethyl-ureido)-propionic acid methyl ester 
• 239789-53-8 methyl N²-benzyloxycarbonyl-N⁶-tert-butoxycarbonyl-2(S),6-diamino-4-azahexanoate 
• 264198-09-6 (2S,2'S,5'S,1''S)-2-Benzyloxycarbonylamino-3-[5'-(1''-tert-butoxycarbonylaminoethyl)tetrahydrofuran-2'-carbamoyl] methyl propionate 
• 264198-10-9 (2S,2'R,5'S,1''S)-2-Benzyloxycarbonylamino-3-[5'-(1''-tert-butoxycarbonylaminoethyl)tetrahydrofuran-2'-carbamoyl] methyl propionate 
• 264197-81-1 (2S,2'R,5'RS)-3-[5'-(4''-Hydroxybutyl)tetrahydrofuran-2'-carbamoyl]-2-benzyloxycarbonylamino methyl propionate 
• 264197-71-9 (2S,2'S,5'R)-3-[5'-(4''-Hydroxybutyl)tetrahydrofuran-2'-carbamoyl]-2-benzyloxycarbonylamino methyl propionate 
• 264197-75-3 (2S,2'S,5'S)-3-[5'-(4''-Hydroxybutyl)tetrahydrofuran-2'-carbamoyl]-2-benzyloxycarbonylamino methyl propionate 
• 264198-05-2 (2S,2'R,5'R,1''S)-3-[5'-(1''-Benzyloxycarbonylamino-4''-tert-butoxycarbonylaminobutyl)tetrahydrofuran-2'-carbamoyl]-2-benzyloxycarbonylamino methyl propionate 
• 578710-41-5 N^α-CBz-DAPA-N^β-(N,N'-di-Boc-β-Lys)-OMe 

Relevant articles and documents

Amide-derived lysine analogues as substrates and inhibitors of histone lysine methyltransferases and acetyltransferases

Histone lysine methyltransferases and acetyltransferases are two classes of epigenetic enzymes that play pivotal roles in human gene regulation. Although they both recognise and posttranslationally modify lysine residues in histone proteins, their difference in histone peptide-based substrates and inhibitors remains to be firmly established. Here, we have synthesised lysine mimics that posses an amide bond linker in the side chain, incorporated them into histone H3 tail peptides, and examined synthetic histone peptides as substrates and inhibitors for human lysine methyltransferases and acetyltransferases. This work demonstrates that histone lysine methyltransferases G9a and GLP do catalyse methylation of the most similar lysine mimic, whereas they typically do not tolerate more sterically demanding side chains. In contrast, histone lysine acetyltransferases GCN5 and PCAF do not catalyse acetylation of the same panel of lysine analogues. Our results also identify potent H3-based inhibitors of GLP methyltransferase, providing a basis for development of peptidomimetics for targeting KMT enzymes.

THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

Sulfate Encapsulation in Supramolecular Structures from L -Asparagine-Derived 2,5-Diketopiperazine Scaffolds: Anion Binding

We report a new sulfate receptor, anchored onto 2,5-diketopiperazine units, which results in the formation of two types of supramolecules; one in which the sulfate ion guest fits snugly into extended cavities and the other in which the guest is sandwiched between layers. In each case, the anion is held by six hydrogen bonds from the host. 1H NMR spectroscopic solution studies enabled the construction of Job plots, and calculation of stoichiometry and association constants. These findings are of possible significance in drug design and for construction of combinatorial libraries.