35804-91-2 Usage
Description
(4aR,7S)-4-Acetyl-6α,9α-epimino-4aβ,5,6,8,9,9aβ-hexahydro-1'-methylspiro[cyclohepta[c]pyran-7(1H),3'-[3H]indol]-2'(1'H)-one, also known as JBIR-94, is a complex chemical compound characterized by its unique spirocyclic structure. With a molecular formula of C24H27NO3 and a molecular weight of 377.47 g/mol, this compound has been the subject of research for its potential pharmacological activities, such as interactions with biological receptors and its role as a therapeutic agent in drug discovery. Further investigation is necessary to fully comprehend its properties and possible applications within the medical and pharmaceutical industries.
Uses
Used in Pharmaceutical Research:
JBIR-94 is utilized as a compound in pharmaceutical research, specifically for exploring its potential interactions with biological receptors and its efficacy as a therapeutic agent. (4aR,7S)-4-Acetyl-6α,9α-epimino-4aβ,5,6,8,9,9aβ-hexahydro-1'-methylspiro[cyclohepta[c]pyran-7(1H),3'-[3H]indol]-2'(1'H)-one's unique structure and properties make it a promising candidate for drug discovery, although more research is required to determine its full potential and applications in medicine.
Used in Drug Discovery:
In the field of drug discovery, JBIR-94 serves as a valuable compound for investigating its possible pharmacological activities. Its complex structure and molecular composition contribute to its potential as a therapeutic agent, making it a subject of interest for further study and development.
Check Digit Verification of cas no
The CAS Registry Mumber 35804-91-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,8,0 and 4 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 35804-91:
(7*3)+(6*5)+(5*8)+(4*0)+(3*4)+(2*9)+(1*1)=122
122 % 10 = 2
So 35804-91-2 is a valid CAS Registry Number.
35804-91-2Relevant articles and documents
Concise Total Synthesis of (?)-Affinisine Oxindole, (+)-Isoalstonisine, (+)-Alstofoline, (?)-Macrogentine, (+)-Na-Demethylalstonisine, (?)-Alstonoxine A, and (+)-Alstonisine
Stephen, Michael Rajesh,Rahman, M. Toufiqur,Tiruveedhula, V. V. N. Phani Babu,Fonseca, German O.,Deschamps, Jeffrey R.,Cook, James M.
supporting information, p. 15805 - 15819 (2017/10/23)
A highly enantio- and diastereoselective strategy to access any member of the sarpagine/macroline family of oxindole alkaloids via internal asymmetric induction was developed from readily available d-(+)-tryptophan. At the center of this approach was the diastereospecific generation of the spiro[pyrrolidine-3,3′-oxindole] moiety at an early stage via a tert-butyl hypochlorite-promoted oxidative rearrangement of a chiral tetrahydro-β-carboline derivative. This key branching point determined the spatial configuration at the C-7 spiro center to be entirely 7R or 7S. Other key stereospecific processes were the asymmetric Pictet–Spengler reaction and Dieckmann cyclization, which were scalable to the 600 and 150 gram levels, respectively. Execution of this approach resulted in first enantiospecific total synthesis of (+)-isoalstonisine and (?)-macrogentine from the chitosenine series (7R), as well as (+)-alstonisine, (+)-alstofoline, (?)-alstonoxine A and (+)-Na-demethylalstonisine from the alstonisine series (7S).
Enantiospecific, stereospecific total synthesis of the oxindole alkaloid alstonisine
Wearing, Xiangyu Z.,Cook, James M.
, p. 4237 - 4240 (2007/10/03)
(equation presented) The total synthesis of alstonisine was accomplished in enantiospecific fashion in an overall yield of 12% (from tryptophan methyl ester) in 17 reaction vessels. The structure of alstonisine (1) has been determined by NOE spectroscopic
