35824-85-2

Basic information

• Product Name: 6-Chloro-5-formyl-1,3-dimethyluracil
• Synonyms: 6-Chloro-5-formyl-1,3-dimethyluracil
• CAS NO: 35824-85-2
• Molecular Formula: C₇H₇ClN₂O₃
• Molecular Weight: 202.59508
• Mol File: 35824-85-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 265.9°Cat760mmHg
• Flash Point: 114.6°C
• Appearance: /
• Density: 1.49g/cm³
• Vapor Pressure: 0.00891mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 6-Chloro-5-formyl-1,3-dimethyluracil(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-5-formyl-1,3-dimethyluracil(35824-85-2)
• EPA Substance Registry System: 6-Chloro-5-formyl-1,3-dimethyluracil(35824-85-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 35824-85-2(Hazardous Substances Data)

Usage

General Description

6-Chloro-5-formyl-1,3-dimethyluracil is a chemical compound with the molecular formula C7H8ClN3O2. It is a derivative of uracil and belongs to the class of heterocyclic compounds. 6-Chloro-5-formyl-1,3-dimethyluracil is a potent inhibitor of thymidine phosphorylase, an enzyme involved in the synthesis and breakdown of DNA. It has also been studied for its potential antitumor and antiviral properties. Additionally, 6-Chloro-5-formyl-1,3-dimethyluracil has been used as a starting material in the synthesis of various pharmaceuticals and agrochemicals. Overall, this compound has shown promising biological activities and potential applications in the fields of medicine and agriculture.

InChI:InChI=1/C7H7ClN2O3/c1-9-5(8)4(3-11)6(12)10(2)7(9)13/h3H,1-2H3

Upstream product

• 769-42-6 1,3-dimethylbarbituric acid 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 114142-97-1 6-(Furan-2-ylmethyl-p-tolyl-amino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 116360-58-8 6-[(4-Chloro-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 114142-96-0 6-[Furan-2-ylmethyl-(4-methoxy-phenyl)-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 116360-55-5 6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 114142-95-9 6-[(4-Ethoxy-phenyl)-furan-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 89550-03-8 6-Chloro-1,3-dimethyl-5-(methyl-phenyl-hydrazonomethyl)-1H-pyrimidine-2,4-dione 
• 114143-00-9 6-(Furan-2-ylmethyl-phenyl-amino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 155185-72-1 6-Chloro-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid phenylamide 
• 36226-12-7 6-chloro-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde phenylhydrazone 
• 89550-02-7 6-Chloro-1,3-dimethyl-5-[(4-nitro-phenyl)-hydrazonomethyl]-1H-pyrimidine-2,4-dione 
• 114143-07-6 6-(Allyl-phenyl-amino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 109519-90-6 6-(N-propargyl)benzylaminopyrimidine-2,4(1H,3H)-dione-5-carbaldehyde 
• 147743-24-6 6-(N-allylbenzylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine 5-carboxaldehyde 
• 114143-08-7 6-[Allyl-(4-methoxy-phenyl)-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 

Relevant articles and documents

Synthesis of some novel annulated pyrido[2,3-d] pyrimidines via stereoselective intramolecular hetero Diels-Alder reactions of 1-oxa-1,3-butadienes

Some novel annulated pyrido[2,3-d]pyrimidines 6 and 7 were synthesized stereoselectively by intramolecular hetero Diels-Alder reactions involving 1-oxa-1,3-butadienes.

The synthesis of pyrimidineisothiazolones. The effect of temperature on the addition of aryl amines to functionalized pyrimidines

A new synthesis for the hither-to-unknown pyrimidine isothiazolones 1 and 2 is detailed. The low temperature selectivity of amine nucleophiles on 6-chloropyrimidine-5-acylbromides (12) for the acylbromide over the ring chloride provides a new procedure fo

Studies of Pyrimidine-2,4-diones: Synthesis of Novel Condensed Pyridopyrimidines via Intramolecular Cycloadditions

Suitably functionalised pyrimidine-2,4-diones (1) cyclised intramolecularly to yield the novel furoisoxazolopyridopyrimidines (5) and (9) in excellent yields.Remarkably, the pyrimidone nucleus was unaffected nor were there any side-reactions in this synthesis.