35852-74-5 Usage
Description
1-Allyl-1H-pyrazole, a pyrazole derivative with the molecular formula C6H8N2, is a chemical compound that features an allyl group attached to the nitrogen atom. It serves as a versatile intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Recognized for its potential in medicine and biological research, 1-allyl-1H-pyrazole demonstrates the ability to inhibit certain enzyme activities, making it a valuable building block for the production of various bioactive molecules. Its contributions to drug discovery and development highlight its significance in the scientific community.
Uses
Used in Pharmaceutical Synthesis:
1-Allyl-1H-pyrazole is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Production:
1-ALLYL-1H-PYRAZOLE also serves as an intermediate in the production of agrochemicals, playing a role in the creation of substances that help protect crops and enhance agricultural productivity.
Used in Organic Compounds Synthesis:
1-Allyl-1H-pyrazole is utilized as a building block in the synthesis of a wide range of organic compounds, showcasing its versatility in chemical reactions and its potential for creating novel molecules with specific applications.
Used in Medicine and Biological Research:
Due to its enzyme-inhibiting properties, 1-allyl-1H-pyrazole is used in medical and biological research to explore its potential applications in treating various diseases and conditions, as well as in understanding biological processes at the molecular level.
Used in Drug Discovery and Development:
As a valuable component in the creation of bioactive molecules, 1-allyl-1H-pyrazole is instrumental in drug discovery and development, where it aids in the identification and synthesis of new pharmaceutical agents with potential therapeutic benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 35852-74-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,8,5 and 2 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 35852-74:
(7*3)+(6*5)+(5*8)+(4*5)+(3*2)+(2*7)+(1*4)=135
135 % 10 = 5
So 35852-74-5 is a valid CAS Registry Number.
35852-74-5Relevant articles and documents
Palladium-Catalyzed Dehydrative Cross-Coupling of Allylic Alcohols and N-Heterocycles Promoted by a Bicyclic Bridgehead Phosphoramidite Ligand and an Acid Additive
Kang, Kyungjun,Kim, Jaewook,Lee, Ansoo,Kim, Woo Youn,Kim, Hyunwoo
supporting information, p. 616 - 619 (2016/02/18)
A mild and efficient dehydrative cross-coupling reaction between allylic alcohols and N-heterocycles using palladium catalysis is reported. A bicyclic bridgehead phosphoramidite (briphos) ligand together with Pd(dba)2 is a highly efficient catalyst, and an acid additive involved in the rate-determining step promotes the catalytic cycle. The coupling reaction of allylic alcohols with N-heterocycles including imidazoles, benzimidazoles, and triazole proceeds under mild reaction conditions with high yields using Pd/briphos and pentafluorophenol.
Synthesis and reactions of the first allenyl azo compounds
Banert, Klaus,Hagedorn, Manfred,Schlott, Jana
, p. 360 - 361 (2007/10/03)
Several propargylhydrazines were prepared and then oxidized by manganese dioxide to generate short-lived 1,1-diazenes, which produced novel allenyl azo compounds (8) through [2,3] sigmatropic rearrangement. Isomerization of 8 or nucleophilic addition to the title compounds lead to hydrazones as well as pyrazole derivatives.
Selective Allylation and Propargylation of Azoles by Phase Transfer Catalysis in the Absence of Solvent
Diez-Barra, Enrique,Hoz, Antonio de la,Loupy, Andre,Sanchez-Migallon, Ana
, p. 1367 - 1374 (2007/10/02)
Phase transfer catalysis without solvent allows the selective preparation of N-allyl- and N-propargylazoles or N-(1-propenyl)- and N-(1,2-propadienyl)azoles by reaction of the parent azole with allyl or propargyl bromides.Small variations in the reaction conditions, base or temperature, afford the desired selectivity.
