35937-24-7Relevant articles and documents
Synthesis, characterization and in vitro hydrolysis of L-pyroglutamyl-L-tryptophan derivatives as potential drug carriers
Bousquet,De Regis,Giannola,Santagati,Tirendi
, p. 260 - 262 (2007/10/02)
The condensation reaction of L-tryptophan with L-pyroglutamic acid or its N-carbobenzyloxy derivative in the presence of dicyclohexylcarbodiimide (DCC) afforded dipeptide molecules identified as L-pyroglutamyl-L-tryptophan derivatives. The synthesized dipeptide molecules offer a potentially useful means to obtain drug carriers and improve the poor uptake of drug molecules to the brain. The chemical hydrolysis characteristics in simulated gastro-intestinal juices are reported. No significant hydrolysis was observed.
