359436-62-7 Usage
Description
11-Maleimidoundecanoic Acid Hydrazide is a heterobifunctional crosslinking reagent characterized by its ability to react with sulfhydryl and carbonyl groups. It is an off-white solid with a spacer arm length of 19.0 Angstroms.
Uses
Used in Biochemical Research:
11-Maleimidoundecanoic Acid Hydrazide is used as a crosslinking agent for the covalent attachment of biomolecules, such as proteins and peptides, to other molecules or surfaces. This is facilitated by its reactive sulfhydryl and carbonyl groups, which enable the formation of stable bonds with target molecules.
Used in Drug Delivery Systems:
In the pharmaceutical industry, 11-Maleimidoundecanoic Acid Hydrazide is utilized as a component in the design and synthesis of drug delivery systems. Its crosslinking properties allow for the creation of stable, biocompatible carriers for the controlled release of therapeutic agents.
Used in Diagnostic Applications:
11-Maleimidoundecanoic Acid Hydrazide is employed as a key component in the development of diagnostic tools, such as immunoassays and biosensors, where its crosslinking capabilities enable the specific binding and detection of target analytes.
Used in Material Science:
In the field of material science, 11-Maleimidoundecanoic Acid Hydrazide is used as a crosslinking agent to improve the mechanical and chemical properties of various materials, such as polymers and hydrogels, for applications in tissue engineering and other advanced technologies.
Check Digit Verification of cas no
The CAS Registry Mumber 359436-62-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,9,4,3 and 6 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 359436-62:
(8*3)+(7*5)+(6*9)+(5*4)+(4*3)+(3*6)+(2*6)+(1*2)=177
177 % 10 = 7
So 359436-62-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H25N3O3/c16-17-13(19)9-7-5-3-1-2-4-6-8-12-18-14(20)10-11-15(18)21/h10-11H,1-9,12,16H2,(H,17,19)
359436-62-7Relevant articles and documents
Preparation method of heterobifunctional protein cross-linking agent having hydrazide structure
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Paragraph 0015, (2019/04/10)
The invention relates to the technical field of preparation of compounds, in particular to a preparation method of a heterobifunctional protein cross-linking agent having a hydrazide structure. The method comprises the following steps: enabling maleimide alkyl acid, i.e., a compound A to be subjected to a heating reaction under the action of a solvent and sulfoxide chloride so as to enable a carboxyl group in the structure of the compound A to be converted into acyl chloride; mixing obtained maleimide alkyl acyl chloride with a solvent and various types of compounds B, and performing an acylation reaction under the action of organic or inorganic alkali so as to generate a compound C; and removing a protecting group at the hydrazine end of the compound C under the action of a solvent and acid or alkali so as to obtain maleimide alkyl hydrazide having the hydrazide structure. According to the method involved in the invention, the cheap and readily available maleimide alkyl acid, as a starting raw material, is prepared into the maleimide alkyl hydrazide by three steps of reactions; the yield of a synthetic route is higher; a product is suitable for the research and development and production of an antibody-drug conjugate; and a synthesis method is simple and convenient to operate, safe and controllable, and suitable for industrial production.
