359687-32-4Relevant articles and documents
Synthesis of new glycopolymers containing β-d-mannopyranose, and c-2-substituted β-d-mannopyranose residues as a new class of inhibitor
Akai, Shoji,Kajihara, Yasuhiro,Nagashima, Yasuhiko,Kamei, Masugu,Arai, Junko,Bito, Masami,Sato, Ken-Ichi
, p. 121 - 143 (2007/10/03)
New styryl monomers containing β-D-mannopyranose, 2-acetamido-2-deoxy-β-D-mannopyranose, 2-deoxy-2-fluoro-β-D-mannopyranose, and 2-deoxy-β-D-arabino-hexopyranose on their side chains, were efficiently synthesized as a new class of a potent inhibitor resistant to exo-α-mannosidase digestion. The binding affinity of the carbohydrate polymers obtained from those mannopyranosyl styryl monomers by radical polymerization with Concanavalin A were evaluated. A binding assay indicated that the multivalency effect and the affinity enhancement attained by modification at the C-2 position of the β-D-mannopyranoside residue resulted in the.