35973-14-9 Usage
General Description
6-Chloro-4-hydroxyquinoline-3-carboxylic acid is a chemical compound that belongs to the quinoline family. It is a derivative of 4-hydroxyquinoline in which a chlorine atom is substituted at the 6th position and a carboxylic acid group is attached at the 3rd position. 6-CHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID has been the subject of pharmaceutical research due to its potential biological activities, including antibacterial and antifungal properties. It can act as a chelating agent and has been studied for its potential use in metal ion sequestration and inhibition of metalloenzymes. Its molecular structure and reactivity make it a promising candidate for further investigation in the development of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 35973-14-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,9,7 and 3 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 35973-14:
(7*3)+(6*5)+(5*9)+(4*7)+(3*3)+(2*1)+(1*4)=139
139 % 10 = 9
So 35973-14-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H6ClNO3/c11-5-1-2-8-6(3-5)9(13)7(4-12-8)10(14)15/h1-4H,(H,12,13)(H,14,15)
35973-14-9Relevant articles and documents
PAPD5 INHIBITORS AND METHODS OF USE THEREOF
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Page/Page column 158, (2020/11/03)
The present application provides compounds that are PAPD5 inhibitors and are useful in treating a variety of conditions such as cancer, telomere diseases, and aging-related and other degenerative disorders.
Antimalarials: Synthesis of 4-aminoquinolines that circumvent drug resistance in malaria parasites
De,Byers,Krogstad
, p. 315 - 320 (2007/10/03)
The strategies described here have permitted the synthesis of a series of 4-aminoquinoline antimalarials. Substantive improvements over previous syntheses include nucleophilic substitution with neat amine rather than in phenol, regioselective reductive alkylation to convert the terminal primary amine (12a-20a) on the diaminoalkane side chain to a diethylamino group, and purification by column chromatography with basic alumina. The 1H nmr spectra obtained after regioselective reductive alkylation with sodium borodeuteride (in comparison with sodium borohydride) demonstrated that this reductive alkylation proceeds via formation and subsequent reduction of the corresponding diamides in situ.
