35978-38-2

Basic information

• Product Name: Thieno[2,3-d]pyrimidin-4(1H)-one, 6-methyl-5-phenyl-
• CAS NO: 35978-38-2
• Molecular Formula: C13H10N2OS
• Molecular Weight: 242.301
• Mol File: 35978-38-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Thieno[2,3-d]pyrimidin-4(1H)-one, 6-methyl-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[2,3-d]pyrimidin-4(1H)-one, 6-methyl-5-phenyl-(35978-38-2)
• EPA Substance Registry System: Thieno[2,3-d]pyrimidin-4(1H)-one, 6-methyl-5-phenyl-(35978-38-2)

Safety Data

• Hazardous Substances Data: 35978-38-2(Hazardous Substances Data)

Upstream product

• 93-55-0 1-phenyl-propan-1-one 
• 4815-37-6 ethyl 2-amino-5-methyl-4-phenylthiophene-3-carboxylate 
• 77287-34-4 formamide 

Downstream Products

• 1018578-66-9 [(6-methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)thio]acetic acid 
• 1175819-21-2 C₁₇H₁₆N₂O₂S₂ 
• 379238-96-7 C₁₃H₁₀N₂S₂ 

Relevant articles and documents

Identification of 4-methoxythieno[2,3-d]pyrimidines as FGFR1 inhibitors

Aim. To identify novel FGFR1 inhibitors using virtual screening approach. Methods. We used methods of organic synthesis, molecular docking via the Autodock 4.2.6 program package and in vitro biochemical tests with γ-32P. Results. In vitro experiments showed that 9 of 23 tested compounds possess inhibitory activity against FGFR1 with IC50 values in the range from 0.9 to 5.6 μM. Conclusions. Nine FGFR1 inhibitors were developed. The mode of compounds binding with the ATP-acceptor site was determined using molecular docking methods and the dependence of the compounds’ activity on the substituents R1, R4 and R5 was evaluated.

Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin- 4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2

A novel series of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids has been synthesized and tested in vitro towards human protein kinase CK2. It was revealed that the most active compounds inhibiting CK2 are 3-{[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio}propanoic acid and 3-{[5-(4-ethoxyphenyl)thieno[2,3-d]pyrimidin-4-yl]thio}propanoic acid (IC 50 values are 0.1 μM and 0.125 μM, respectively). Structure-activity relationships of 28 tested thienopyrimidine derivatives have been studied and binding mode of this chemical class has been predicted. Evaluation of the inhibitors on seven protein kinases revealed considerable selectivity towards CK2.

THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS

The present invention provides thienopyrimidine compounds which are potasium channels inhibitors. Pharmaceutical compositions comprising the compounds and their use in the treatment of arrhythmia are also provided.