35980-65-5Relevant articles and documents
Convenient method for preparation of aza-crown ethers
Blǎni?ǎ, Gabriela,Buc?a, Monica,Vlassa, Mircea
, p. 1569 - 1573 (2007/10/03)
A convenient method for the preparation of peraza crown ethers in a one-pot synthesis in the presence of KF/Al2O3 is presented. Copyright Taylor & Francis Group, LLC.
An efficient route to symmetrically and unsymmetrically substituted azamacrocyclic ligands
Pulacchini, Sonia,Watkinson, Michael
, p. 4233 - 4238 (2007/10/03)
An extremely efficient cyclisation protocol has been developed for the synthesis of symmetrically (6) and unsymmetrically substituted (7) derivatives of 1,4,7-triazacyclononane (2). The optimised conditions can be successfully applied to the synthesis of larger macrocycles 15a and 18a. In contrast, the protocol is not generally applicable with benzylamine, and the cyclic carbamates 16 and 19, rather than larger azamacrocycles, are formed, indicating that cyclisation in CH3CN using K2CO3 is highly specific to the formation of 7.
Improved Richman-Atkins Syntheses of Cyclic Polyamines Particularly 1,4,7-Triazacyclononane (tacn) and 1,4,7-Triazacyclodecane (tacd), with the Aid of Cation-Exchange in Purification and Isolation
Searle, Graeme H.,Geue, Rodney J.
, p. 959 - 970 (2007/10/02)
Richman-Atkins cyclization syntheses for the cyclic triamines 1,4,7-triazacyclononane (tacn) and 1,4,7-triazacyclodecane (tacd) with the alternative possible sets of reagents asd tosyl derivatives have been examined in detail and compared.The cyclizations from the tritosyl derivative of diethylenetriamine (dientt) and the appropriate diols as ditosylates proceeded relatively cleanly, although there were small amounts of higher products and some carry through of dientt for tacn.The alternative cyclizations, from 2,2'-(tosylimino)bisethyl ditosylate and a ditosyl diamine, gave little reaction to form tacn as the tritosyl derivative.The reaction to form tritosyl tacd proceeded further, but was accompanied by significant formation of higher condensation products, particularly the hexamines 1,4,7,11,14,17-hexaazacycloeicosane (2:2 cyclic dimer) and 3,7,10,13-tetraazahexadecane-1,16-diamine.A cation-exchange procedure, applied after the detosylation stage, is described for obtaining the required pure 1 : 1 cyclic polyamines as their hydrochloride salts with high recovery.This is an effective method for removing higher co-products.These may be recovered, and by this means the above hexamines were isolated in admixture.