35981-68-1

Basic information

• Product Name: 4-(Cyclopropylcarbonyl)benzeneacetic acid
• Synonyms: 4-(Cyclopropylcarbonyl)benzeneacetic acid;SQ-20650;2-(4-(Cyclopropanecarbonyl)phenyl)acetic acid
• CAS NO: 35981-68-1
• Molecular Formula: C₁₂H₁₂O₃
• Molecular Weight: 204.22
• Mol File: 35981-68-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 398.3°C at 760 mmHg
• Flash Point: 208.9°C
• Appearance: /
• Density: 1.295g/cm³
• Vapor Pressure: 4.63E-07mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 4-(Cyclopropylcarbonyl)benzeneacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Cyclopropylcarbonyl)benzeneacetic acid(35981-68-1)
• EPA Substance Registry System: 4-(Cyclopropylcarbonyl)benzeneacetic acid(35981-68-1)

Safety Data

• Hazardous Substances Data: 35981-68-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H12O3/c13-11(14)7-8-1-3-9(4-2-8)12(15)10-5-6-10/h1-4,10H,5-7H2,(H,13,14)

Upstream product

• 7143-76-2 cyclopropyl-p-tolyl-methanone 
• 169280-08-4 meta-(4-chloro-1-oxobutyl)benzene acetic acid ethyl ester 
• 169280-07-3 para-(4-chloro-1-oxobutyl)benzene acetic acid ethyl ester 
• 108-88-3 toluene 
• 35981-66-9 (4-Bromomethyl-phenyl)-cyclopropyl-methanone 
• 35981-67-0 (4-cyclopropanecarbonyl-phenyl)-acetonitrile 

Downstream Products

• 35981-69-2 (α-Cyclopropyl-p-tolyl)essigsaeure 
• 50664-66-9 p-(Cyclopropylhydroxymethyl)-phenethyl-alkohol 
• 50664-68-1 (4-Cyclopropanecarbonyl-phenyl)-acetamide 
• 50829-28-2 2,3-Bis-(4-cyclopropanecarbonyl-phenyl)-propionic acid 
• 35981-86-3 (4-Cyclopropanecarbonyl-phenyl)-acetic acid, ethyl ester 
• 35982-02-6 4-(cyclopropylcarbonyl)-benzeneacetic acid,methyl ester 
• 50664-67-0 2-(4-Cyclopropanecarbonyl-phenyl)-N-hydroxy-acetamide 
• 35982-03-7 Methyl-p-(cyclopropylcarbonyl)-hydratropat 
• 35982-04-8 2-(4-cyclopropanecarbonyl-phenyl)-propionic acid 
• 35981-70-5 (α-Cyclopropyl-α-hydroxy-p-tolyl)essigsaeure 
• 35981-81-8 p-(Cyclopropylmethyl)-hydratropinsaeure 
• 35981-97-6 p-(Cyclopropylmethyl)phenaethyl-alkohol 
• 50664-69-2 Isopropyl-p-(cyclopropylcarbonyl)phenylacetat 

Relevant articles and documents

ANTIHISTAMINIC PIPERIDINE DERIVATIVES AND INTERMEDIATES FOR THE PREPARATION THEREOF

This invention relates to novel piperidine derivatives of formula (I) and a process for the preparation thereof, wherein R1 is H or C1-C6alkyl wherein the C1-C6alkyl moiety is straight or branched; R2 is -COOH or -COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; or stereoisomers or pharmaceutically acceptable acid addition salt thereof.

Novel antihistaminic piperidine derivatives and intermediates for the preparation thereof

This invention relates to novel piperidine derivatives of formula (I) and a process for the preparation thereof. wherein R1 is H or C1-C6alkyl wherein the C1-C6alkyl moiety is straight or branched; R2 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; or stereoisomers or pharmaceutically acceptable acid addition salt thereof.

Intermediates useful for the preparation of antihistaminic piperidine derivatives

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C(═O)— or —CH(OH)—; R1represents hydrogen or hydroxy; R2represents hydrogen; R1and R2taken together form a second bond between the carbon atoms bearing R1and R2; n is an integer of from 1 to 5; m is an integer 0 or 1; R3is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1and R2are taken together to form a second bond between the carbon atoms bearing R1and R2or where R1represented hydroxy, m is an integer 0.