36041-80-2

Basic information

• Product Name: (2R,3S)-methyl 3-hydroxy-2-methyl-3-phenylpropanoate
• Synonyms: (2R,3S)-methyl 3-hydroxy-2-methyl-3-phenylpropanoate
• CAS NO: 36041-80-2
• Molecular Weight: 194.23
• Mol File: 36041-80-2.mol
• Article Data: 110

Chemical Properties

• CAS DataBase Reference: (2R,3S)-methyl 3-hydroxy-2-methyl-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-methyl 3-hydroxy-2-methyl-3-phenylpropanoate(36041-80-2)
• EPA Substance Registry System: (2R,3S)-methyl 3-hydroxy-2-methyl-3-phenylpropanoate(36041-80-2)

Safety Data

• Hazardous Substances Data: 36041-80-2(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 67-56-1 methanol 
• 5445-17-0 Methyl 2-bromopropionate 
• 62841-79-6 (3R,4R)-2,2-Dimethoxy-3-methyl-4-phenyl-oxetane 
• 554-12-1 propanoic acid methyl ester 
• 72658-09-4 (E)-(1-methoxyprop-1-enyloxy)trimethylsilane 
• 84784-64-5 (Z)-Dimethyl(1,1-dimethylethyl)<(1-methoxy-1-propenyl)oxy>silane 
• 84784-58-7 (E)-[(1-methoxy)-propenyloxy]-tert-butyldimethylsilane 
• 37612-61-6 1-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one 
• 166588-79-0 1-((4R,7S)-7-Isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-indazol-2-yl)-3-phenyl-propan-1-one 
• 34880-70-1 [1-methoxyprop-1-enyloxy]trimethylsilane 
• 18020-59-2 methyl 3-hydroxy-2-methylidene-3-phenylpropionate 
• 124957-36-4 Methyl 3-acetoxy-2-methylene-3-phenylpropanoate 
• 281195-04-8 2-methoxycarbonyl-1-phenyl-1-trimethylsilyloxypropene 

Downstream Products

• 36393-58-5 anti-3-hydroxy-2-methyl-3-phenylpropanylamine 
• 36391-82-9 5r-methyl-6t-phenyl-[1,3]oxazinan-2-one 
• 94199-26-5 (2S,3R)-methyl 3-hydroxy-2-methyl-3-phenylpropionate 
• 7087-77-6 (1S,2S)-2-methyl-1-phenyl-propane-1,3-diol 
• 36041-79-9 (-)-(2R,3S)-3-hydroxy-2-methyl-3-phenylpropionic acid 

Relevant articles and documents

Application of axially dissymmetric ligand recoverable with fluorous solvent as a chiral auxiliary

(Ra)-(R)2-2,2′-Bis(1-hydroxy-1H-perfluorooctyl)biphenyl ((Ra)-(R)2-1c), which is an axially dissymmetric ligand with two chiral centers, works as a good chiral auxiliary for asymmetric aldol reaction. Thus, the reaction of monopropan

Visible-Light-Driven, Metal-Free Divergent Difunctionalization of Alkenes Using Alkyl Formates

In recent decades, difunctionalization of alkenes has received considerable attention as an efficient and straightforward way to increase molecular complexity. However, examples of the difunctionalization of alkenes initiated by the intermolecular addition of alkoxycarbonyl radicals providing substituted alkanoates are still rare. Herein, we present the visible light-driven metal-free divergent difunctionalization of alkenes triggered by the intermolecular addition of alkoxycarbonyl radicals under ambient conditions. Employing alkyl formates as precursors of alkoxycarbonyl radicals and 4CzIPN as the photocatalyst, a variety of substituted alkanoates, including β-alkoxy, β-hydroxy, β-dimethoxymethoxy, and β-formyloxy alkanoates, could be facilely accessed with high functional group tolerance and high efficiency. Moreover, the mechanism study revealed that β-hydroxy alkanoates were generated by a selective decomposition of orthoformates promoted by the N-alkoxyazinium salt.

Manganese-Catalyzed anti-Selective Asymmetric Hydrogenation of α-Substituted β-Ketoamides

A Mn-catalyzed diastereo- and enantioselective hydrogenation of α-substituted β-ketoamides has been realized for the first time under dynamic kinetic resolution conditions. anti-α-Substituted β-hydroxy amides, which are useful building blocks for the synthesis of bioactive molecules and chiral drugs, were prepared in high yields with excellent selectivity (up to >99 percent dr and >99 percent ee) and unprecedentedly high activity (TON up to 10000). The origin of the excellent stereoselectivity was clarified by DFT calculations.