36051-31-7

Basic information

• Product Name: Guanosine 5'-triphosphate trisodium salt
• Synonyms: GUANOSINE-5'-TRIPHOSPHATE TETRASODIUM SALT;Guanosine 5′-triphosphate sodium salt hydrate;Guanosine 5'-(tetrahydrogen triphosphate), trisodium salt;GUANOSINE 5'-TRIPHOSPHATE SODIUM 100 MM SOLUTION MO;GUANOSINE 5'-TRIPHOSPHATE SODIUM*PREPARE D ENZYMATIC;GUANOSINE-5'-TRIPHOSPHATE TRISODIUM SALT HYDRATE 95+% HPLC;guanosine 5'-triphosphate sodium salt solution;Guanosine 5'-triphosphate trisodium salt
• CAS NO: 36051-31-7
• Molecular Formula: C₁₀H₁₃N₅O₁₄P₃*3Na
• Molecular Weight: 589.13
• EINECS: 252-847-2
• Mol File: 36051-31-7.mol
• Article Data: 1

Chemical Properties

• Appearance: white/powder
• Storage Temp.: −70°C
• Solubility: H2O: 50 mg/mL
• Stability: Hygroscopic
• BRN: 4113439
• CAS DataBase Reference: Guanosine 5'-triphosphate trisodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Guanosine 5'-triphosphate trisodium salt(36051-31-7)
• EPA Substance Registry System: Guanosine 5'-triphosphate trisodium salt(36051-31-7)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25-36/37/38-39/23/24/25
• Safety Statements: 26-36/37/39-45
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 36051-31-7(Hazardous Substances Data)

Usage

Description

Guanosine 5'-triphosphate trisodium salt, commonly known as GTP trisodium salt, is a nucleotide that plays a crucial role in various cellular processes. It is a disodium salt supplied in crystal form and is an essential component in the study and understanding of cellular signaling pathways.

Uses

Used in Biochemical Research:
Guanosine 5'-triphosphate trisodium salt is used as a reagent for biochemical research, specifically in the reconstitution of transducin during the purification process of transducin. Transducin is a protein involved in the signal transduction pathway, and GTP trisodium salt is essential for its proper functioning and study.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, GTP trisodium salt is utilized as an active ingredient or a component in the development of drugs targeting various diseases. Its role in cellular processes makes it a valuable compound for drug discovery and therapeutic applications.
Used in Diagnostic Applications:
Guanosine 5'-triphosphate trisodium salt is also used in diagnostic applications, where it may serve as a marker or a component in the development of diagnostic tools and tests for various medical conditions.
Overall, Guanosine 5'-triphosphate trisodium salt is a versatile compound with applications in biochemical research, pharmaceutical development, and diagnostic applications, making it an important substance in the field of life sciences.

Biochem/physiol Actions

GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

Upstream product

• 69281-33-0 Guanosine 5'-monophosphate imidazolide 
• 85-32-5 Guanosine 5'-monophosphate 
• 127070-83-1 guanosine 5-monophosphate mono(trioctylammonium) salt 

Downstream Products

• 991-43-5 guanosine 5'-diphospho-D-mannose 

Relevant articles and documents

Convenient syntheses of cytidine 5'-triphosphate, guanosine 5'-triphosphate, and uridine 5'-triphosphate and their use in the preparation of UDP-glucose, UDP-glucuronic acid, and GDP-mannose

This paper compares enzymatic and chemical methods for the synthesis of cytidine 5'-triphosphate, guanosine 5'-triphosphate, and uridine 5'-triphosphate from the corresponding nucleoside monophosphates on scales of ~10 g. These nucleoside triphosphates are important as intermediates in Leloir pathway biosyntheses of complex carbohydrates; the nucleoside monophosphates are readily available commercially. The best route to CTP is based on phosphorylation of CMP using adenylate kinase (EC 2.7.4.3); the route to GTP involves phosphorylation of GMP using guanylate kinase (EC 2.7.4.8); chemical deamination of CTP (prepared enzymatically from CMP) is the best synthesis of UTP. For the 10-200-mmol-scale reactions described in this paper, it is more convenient to prepare phosphoenolpyruvate (PEP), used in the enzymatic preparations, from D-(-)-3-phosphoglyceric acid (3-PGA) in the reaction mixture rather than to synthesize PEP in a separate chemical step. The in situ conversion of 3-PGA to PEP requires the coupled action of phosphoglycerate mutase (EC 2.7.5.3) and enolase (EC 4.2.1.11). The enzyme-catalyzed syntheses of uridine 5'-diphosphoglucose (UDP-Glc), uridine 5'-diphosphoglucuronic acid (UDP-GlcUA), and guanosine 5'-diphosphomannose (GDP-Man) illustrate the use of the nucleoside triphosphates.