36053-96-0

Basic information

• Product Name: 7-METHYL-2,3-DIHYDROQUINOLIN-4(1H)-ONE
• Synonyms: 7-METHYL-2,3-DIHYDROQUINOLIN-4(1H)-ONE;7-Methyl-2,3-Dihydroquinolin-4(1H)-One(WX604451)
• CAS NO: 36053-96-0
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2
• Mol File: 36053-96-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-METHYL-2,3-DIHYDROQUINOLIN-4(1H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHYL-2,3-DIHYDROQUINOLIN-4(1H)-ONE(36053-96-0)
• EPA Substance Registry System: 7-METHYL-2,3-DIHYDROQUINOLIN-4(1H)-ONE(36053-96-0)

Safety Data

• Hazardous Substances Data: 36053-96-0(Hazardous Substances Data)

Upstream product

• 38560-26-8 1-(m-tolyl)azetidin-2-one 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 76227-95-7 ethyl N-(3-methylphenyl)-b-aminopropionate 
• 108-44-1 1-amino-3-methylbenzene 
• 82121-08-2 4-hydroxy-7-methylquinoline 
• 38560-21-3 N-m-Tolyl-3-brompropionamid 

Downstream Products

• 82121-08-2 4-hydroxy-7-methylquinoline 

Relevant articles and documents

MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF

The disclosure relates to compounds and pharmaceutical compositions capable of modulating the hydroxysteroid 17-beta dehydrogenase (HSD17B) family member proteins including inhibiting the HSD17B member proteins, e.g. HSD17B13. The disclosure further relates to methods of treating liver diseases, disorders, or conditions with the compounds and pharmaceutical compositions disclosed herein, in which the HSD17B family member protein plays a role.

Formation of 2,3-Dihydro-4(1H)-quinolones and Related Compounds via Fries-type Acid-catalysed Rearrangement of 1-Arylazetidin-2-ones

A variety of 1-arylazetidin-2-ones were treated with trifluoroacetic acid under reflux, methanesulphonic acid at 100 deg C, or conc. sulphuric acid to give the corresponding 2,3-dihydro-4(1H)-quinolones via acyl migration and N-CO fission.In the case of 1-(3-substituted phenyl)azetidin-2-ones, two positional isomeric products, 5- and 7-substituted 2,3-dihydro-4(1H)-quinolones were obtained. 4-Methyl, 4-ethoxycarbonyl, and 4-piperidin-2-yl-1-arylazetidin-2-ones and their analogues were also converted into the corresponding 2-substituted 2,3-dihydro-4(1H)-quinolones under acidic conditions.The 3-substituted 1-phenylazetidin-2-ones (36) and (37) were converted into the furoquinoline systems (38) and (40), respectively, by application of this method.