36076-26-3

Basic information

• Product Name: 1,4-PHENYLENEDIACETIC ACID DIETHYL ESTER
• Synonyms: DIETHYL 1,4-PHENYLENEDIACETATE;1,4-PHENYLENEDIACETIC ACID DIETHYL ESTER;(1,4-Phenylene)bis(acetic acid ethyl) ester;1,4-Benzenediacetic acid diethyl ester;1,4-Phenylenediacetate diethyl ester;1,4-Benzenediacetic Acid Diethyl Ester (9CI);Diethyl 1,4-Benzenediacetate;NSC 139681
• CAS NO: 36076-26-3
• Molecular Formula: C₁₄H₁₈O₄
• Molecular Weight: 250.29
• Mol File: 36076-26-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 59 °C
• Boiling Point: 140 °C / 4mmHg
• Flash Point: 160.1 °C
• Appearance: /
• Density: 1.097 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1,4-PHENYLENEDIACETIC ACID DIETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-PHENYLENEDIACETIC ACID DIETHYL ESTER(36076-26-3)
• EPA Substance Registry System: 1,4-PHENYLENEDIACETIC ACID DIETHYL ESTER(36076-26-3)

Safety Data

• Hazardous Substances Data: 36076-26-3(Hazardous Substances Data)

Usage

Description

1,4-Phenylenediacetic Acid Diethyl Ester is an aromatic diester compound characterized by its chemical structure that features a phenyl ring with two ester groups attached to the 1 and 4 positions. This molecule is known for its potential applications in various industries due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
1,4-Phenylenediacetic Acid Diethyl Ester is used as a key intermediate in the synthesis of potent β-3 receptor agonists. These agonists play a crucial role in the development of medications targeting conditions such as obesity, diabetes, and other metabolic disorders. 1,4-PHENYLENEDIACETIC ACID DIETHYL ESTER's ability to interact with β-3 receptors makes it a valuable component in the design and production of these therapeutic agents.

Upstream product

• 64-17-5 ethanol 
• 622-75-3 1,4-phenylenediacetonitrile 
• 105077-01-8 diethyl α-methylthio-1,4-benzenediacetate 
• 7325-46-4 1,4-phenylenediacetic acid 
• 101-97-3 Ethyl 2-phenylethanoate 
• 872-31-1 3-Bromothiophene 
• 105-53-3 diethyl malonate 
• 106-39-8 bromochlorobenzene 
• 624-38-4 para-diiodobenzene 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 101872-93-9 p-phenylenedi-acetic acid bis-(2-dimethylamino-ethyl ester) 
• 5140-03-4 2-[4-(2-hydroxyethyl)phenyl]ethan-1-ol 
• 108666-73-5 (cis-cyclohexane-1,4-diyl)-di-acetic acid diethyl ester 
• 151162-36-6 diethyl 2-nitrobenzene-1,4-diacetate 
• 109588-07-0 p-phenylenedi-acetic acid ethyl ester-(2-diethylamino-ethyl ester) 
• 7325-46-4 1,4-phenylenediacetic acid 
• 104183-09-7 benzenediethanol-1,1,1',1'-d4 
• 79815-73-9 p-phenylene-bis-(diethyl malonate) 
• 874338-61-1 1-phenyl-4-[4-(2-hydroxy-4-phenyl-3-butynyl)phenyl]but-3-yn-2-ol 
• 39246-00-9 p-phenylenediacetaldehyde 
• 104183-00-8 divinylbenzene-2,2,2',2'-d4 
• 79815-74-0 1,4-bis(3,5-dihydroxypyrazol-4-yl)benzene 
• 101566-05-6 indolone-6-acetic acid 
• 300548-39-4 diethyl 2-aminobenzene-1,4-diacetate 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF

The present invention provides a heterocyclic compound represented by the formula (I), its stereoisomers, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and their use in preparing a medicament for the prevention and/or treatment of central nervous system disease.

Practical synthesis of 2-arylacetic acid esters via palladium-catalyzed dealkoxycarbonylative coupling of malonates with aryl halides

A new palladium-based system was developed that catalyzes the coupling of aryl halides with diethyl malonates in the presence of mild bases. In the course of the reaction, the intermediately formed diethyl arylmalonate is directly converted into the arylacetic acid ester via liberation of carbon dioxide and an alkanol. This cross-coupling/dealkoxycarbonylation process provides an efficient and high-yielding synthetic entry to diversely functionalized arylacetic acid esters. Two complementary protocols were developed, one of which is optimal for electron-rich, the other for electron-poor aryl halides. Both make use of low loadings of palladium(0) bis(dibenzylideneacetone) (0.5 mol%)/tri-tert-butylphosphonium tetrafluoroborate (1.1 mol%) as the catalyst and diethyl malonate as the reaction solvent. The new procedures are particularly effective for sterically hindered substrates. Copyright

Synthesis of naphthalenes and 2-naphthols by the electrophilic cyclization of alkynes

A wide variety of substituted naphthalenes are readily prepared regioselectively under mild reaction conditions by the 6-endo-dig electrophilic cyclization of appropriate arene-containing propargylic alcohols by IC1, I 2, Br2, NBS, and PhSeBr. 3-Iodo-2-naphthols have also been prepared in excellent yields by the cyclization of analogous 1-aryl-3-alkyn-2-ones. This methodology readily accommodates various functional groups and has been successfully extended to the synthesis of substituted carbazoles and dibenzothiophenes.