36085-73-1

Basic information

• Product Name: B-HT 920 DIHYDROCHLORIDE
• Synonyms: 5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepin-2-amineDihydrochloride,6-Allyl-2-amino-5,6,7,8-tetrahydro-4;B-HT920dihydrochlorideTalipexole;5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepin-2-amine Dihydrochloride, 6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine Dihydrochloride;Talipexole, 5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride;5,6,7,8-Tetrahydro-6-(2-propen-1-yl)-4H-thiazolo[4,5-d] azepin-2-amine dihydrochloride;talipexole hydrochloride;6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride;2-Amino-6-allyl-4,5,7,8-tetrahydro-6H-thiazolo(5,4-D)azepin-dihydrochlorid [german]
• CAS NO: 36085-73-1
• Molecular Formula: C10H17Cl2N3S
• Molecular Weight: 282.23
• Product Categories: All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;Adrenoceptor
• Mol File: 36085-73-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 245°C dec.
• Boiling Point: 364.6 °C at 760 mmHg
• Flash Point: 174.3 °C
• Appearance: off-white/solid
• Vapor Pressure: 1.66E-05mmHg at 25°C
• Storage Temp.: Desiccate at RT
• Solubility: H2O: >20 mg/mL
• CAS DataBase Reference: B-HT 920 DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: B-HT 920 DIHYDROCHLORIDE(36085-73-1)
• EPA Substance Registry System: B-HT 920 DIHYDROCHLORIDE(36085-73-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• RTECS: XJ7050340
• Hazardous Substances Data: 36085-73-1(Hazardous Substances Data)

Usage

Description

B-HT 920 DIHYDROCHLORIDE is a potent agonist of dopamine 2 (D2) receptors, with a high affinity (Ki = 5.8 nM) and selectivity for D2 over D3 and D4 receptors. It also acts as an agonist of α2-adrenergic receptors and an antagonist of serotonin-3 (5-HT3; Ki = 0.35 μM) receptors. B-HT 920 DIHYDROCHLORIDE exhibits neuroprotective and regenerative effects in animal models of Parkinson's disease. It is a light yellow solid.

Uses

Used in Pharmaceutical Industry:
B-HT 920 DIHYDROCHLORIDE is used as an antiparkinson reagent for its neuroprotective and regenerative effects in animal models of Parkinson's disease. It modulates the dopaminergic system, which is crucial for the treatment of Parkinson's disease, by acting as an agonist of dopamine 2 (D2) receptors.
Used in Research Applications:
B-HT 920 DIHYDROCHLORIDE is used as a research tool for studying the roles of dopamine 2 (D2) receptors, α2-adrenergic receptors, and serotonin-3 (5-HT3) receptors in various neurological and psychiatric conditions. Its agonistic and antagonistic properties make it a valuable compound for understanding receptor interactions and developing new therapeutic strategies.

Biological Activity

Dopamine D 2 receptor agonist, α 2 -adrenoceptor agonist and 5-HT 3 receptor antagonist. Displays antiParkinsonian activity.

InChI:InChI=1/C10H15N3S.2ClH/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8;;/h2H,1,3-7H2,(H2,11,12);2*1H