361-09-1 Usage
Description
Sodium cholate is a white to off-white powder with non-denaturing detergent properties, which makes it suitable for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
Sodium cholate is used as a solubilizing agent for enhancing the solubility of poorly water-soluble drugs, facilitating their absorption and bioavailability in the body.
Used in Research and Diagnostics:
Sodium cholate is used as a component in the formulation of various diagnostic reagents and research tools, such as in vitro diagnostic assays and cell culture media, due to its ability to stabilize and solubilize membrane proteins.
Used in Membrane Protein Extraction:
Sodium cholate is used as a non-denaturing detergent for membrane protein extraction, allowing researchers to isolate and study membrane proteins without disrupting their native structure and function.
Used in Drug Delivery Systems:
Sodium cholate is used as a component in the development of drug delivery systems, particularly for hydrophobic drugs, to improve their solubility, stability, and targeted delivery to specific tissues or organs.
Used in Food Industry:
Sodium cholate is used as an emulsifying agent in the food industry, helping to mix and stabilize ingredients that are not naturally soluble together, such as oil and water, to create a uniform and stable product.
Used in Cosmetics Industry:
Sodium cholate is used as a solubilizing agent in the formulation of cosmetics, particularly for products containing hydrophobic active ingredients, to enhance their solubility and effectiveness in skincare and personal care products.
Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NazO. See also CHOLIC ACID.
Check Digit Verification of cas no
The CAS Registry Mumber 361-09-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,6 and 1 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 361-09:
(5*3)+(4*6)+(3*1)+(2*0)+(1*9)=51
51 % 10 = 1
So 361-09-1 is a valid CAS Registry Number.
InChI:InChI=1/C24H40O5.Na/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);/q;+1/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;/m1./s1
361-09-1Relevant articles and documents
Synthesis, characterization and biological activity of hydroxyl- bisphosphonic analogs of bile acids
Bortolini, Olga,Fantin, Giancarlo,Fogagnolo, Marco,Rossetti, Stefano,Maiuolo, Loredana,Di Pompo, Gemma,Avnet, Sofia,Granchi, Donatella
experimental part, p. 221 - 229 (2012/07/28)
Bisphosphonates (BPs) are now the most widely used drugs for diseases associated with increased bone resorption, such as osteoporosis, and tumor bone diseases. A significant drawback of the BPs is their poor oral absorption that is enhanced by the presence of bile acid substituents in the bisphosphonate framework, with no toxic effects. A straightforward synthesis of bile acid-containing hydroxy-bisphosphonates and a full characterization of these pharmaceutically important molecules, including an evaluation of affinity and the mechanism of binding to hydroxyapatite, is presented. The biological activity of bile acid-containing bisphosphonate salts was determined using the neutral-red assay on the L929 cell line and primary cultures of osteoclasts. The bioactivity of the new compounds was found superior than bisphosphonates of established activity.