361-73-9

Basic information

• Product Name: 2-(TRIFLUOROACETYL)CYCLOPENTANONE
• Synonyms: 2-(TRIFLUOROACETYL)CYCLOPENTANONE;AKOS B029512;Cyclopentanone, 2-(trifluoroacetyl)- (7CI,8CI,9CI);Cyclopentanone, 2-(2,2,2-trifluoroacetyl)-
• CAS NO: 361-73-9
• Molecular Formula: C₇H₇F₃O₂
• Molecular Weight: 180.12
• Product Categories: ACETYLHALIDE
• Mol File: 361-73-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 66 °C(Press: 21-22 Torr)
• Appearance: /
• Density: 1.355±0.06 g/cm3(Predicted)
• PKA: 7.74±0.20(Predicted)
• CAS DataBase Reference: 2-(TRIFLUOROACETYL)CYCLOPENTANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TRIFLUOROACETYL)CYCLOPENTANONE(361-73-9)
• EPA Substance Registry System: 2-(TRIFLUOROACETYL)CYCLOPENTANONE(361-73-9)

Safety Data

• Hazardous Substances Data: 361-73-9(Hazardous Substances Data)

Usage

General Description

2-(Trifluoroacetyl)cyclopentanone is a chemical compound with the molecular formula C8H9F3O. It is a cyclic ketone with a trifluoroacetyl group attached to the cyclopentanone ring. 2-(TRIFLUOROACETYL)CYCLOPENTANONE is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential use in the development of new materials and as a reagent in organic chemistry reactions. It is known for its strong electron-withdrawing properties due to the presence of the trifluoroacetyl group, making it a valuable intermediate in organic synthesis. Additionally, its unique structure and reactivity make it a valuable tool in the research and development of new chemical compounds.

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 120-92-3 cyclopentanone 

Downstream Products

• 347361-46-0 3-trifluoromethyl-5,6-dihydro-1,4-H-cyclopenta[d]-pyrazole 
• 371967-27-0 3-cyano-4-trifluoromethyl-6,7-dihydro-2(1,5H)-cyclopenta[e]pyridone 
• 428834-02-0 2-methyl-3-phenyl-8-(trifluoromethyl)-6,7-dihydro-5H-1,4,8a-triaza-s-indacene 
• 434299-40-8 3-(4-chlorophenyl)-8-trifluoromethyl-6,7-dihydro-5H-1,4,8a-triaza-s-indacene 
• 1207102-77-9 3-(4-chlorophenyl)-5-(trifluoromethyl)-6,7,8,9-tetrahydropyrazolo[1,5-a]quinazoline 
• 1207102-70-2 3-(4-chlorophenyl)-9-(trifluoromethyl)-5,6,7,8-tetrahydropyrazolo[5,1-b]quinazoline 
• 1207102-81-5 3-(4-chlorophenyl)-8-(trifluoromethyl)-6,7,7a,8-tetrahydro-4H-cyclopenta[d]pyrazolo[1,5-a]pyrimidine-4a,8(5H)-diol 
• 428835-78-3 2-(4-chlorophenyl)-8-trifluoromethyl-6,7-dihydro-5H-1,4,8a-triaza-s-indacene 
• 1207102-73-5 2-(4-chlorophenyl)-5-trifluoromethyl-7,8-dihydro-6H-1,4,8b-triaza-as-indacene 
• 1207102-76-8 2-(4-chlorophenyl)-5-(trifluoromethyl)-6,7,8,9-tetrahydropyrazolo[1,5-a]quinazoline 
• 428844-05-7 2-(4-chlorophenyl)-9-(trifluoromethyl)-5,6,7,8-tetrahydropyrazolo[5,1-b]quinazoline 

Relevant articles and documents

2-oxadiazole-3-aminothiophene thieno-[2,3-b] pyridine derivative and preparing method and application thereof

The invention belongs to the field of chemical pharmaceuticals, and particularly relates to a 2-oxadiazole-3-aminothiophene thieno-[2,3-b] pyridine derivative and a preparing method and application thereof. The structure of the 2-oxadiazole-3-aminothiophene thieno-[2,3-b] pyridine derivative is shown in the formula I. A compound of the 2-oxadiazole-3-aminothiophene thieno-[2,3-b] pyridine derivative has the good HCV inhibitory effect, and meanwhile shows the low cytotoxicity, and a new method is provided for development of an anti-HCV inhibitor. The general formula is defined in the description.

Highly selective trifluoroacetic ester/ketone metathesis: An efficient approach to trifluoromethyl ketones and esters

A highly selective and atom efficient 'trifluoroacetic ester/ketone metathesis' has been sincerely witnessed. Enolizable alkyl (at least two non-hydrogen atoms) aryl ketones were found to react readily with ethyl trifluoroacetate under the promotion of NaH to afford trifluoroacetic ester/ketone exchange products, trifluoromethyl ketones (TFMKs), and aromatic acid esters, which were quite different from the general Claisen condensation products, 1,3-diketones. The outcome of the reaction between ketone and ethyl trifluoroacetate is strongly related to the structures of substrates, the steric congestion caused by alkyl group is in favor of the C-C bond cleavage. DFT investigation further disclosed that the metathesis reaction was a kinetically favored pathway. Using only a slight excess of cheap trifluoromethylation reagent, simple operation and mild conditions make it a practical method for preparation of TFMKs on large scale, as well as a new choice of converting aryl alkyl ketones to aromatic acid esters.

Metal and boron derivatives of fluorinated cyclic 1,3-dicarbonyl compounds

Starting from the corresponding cyclic 1,3-diketones or other precursors (cyclic ketones as well as lactones), several new salts and chelate complexes of fluorinated 1,3-dicarbonyls were obtained. Their preparative significance was demonstrated by straigh