361436-27-3

Basic information

• Product Name: tert-Butyl 4-bromo-3,5-dimethylphenylcarbamate
• Synonyms: N-Boc 4-bromo-3,5-dimethylaniline;tert-Butyl 4-bromo-3,5-dimethylphenylcarbamate
• CAS NO: 361436-27-3
• Molecular Formula: C₁₃H₁₈BrNO₂
• Molecular Weight: 300.19152
• Mol File: 361436-27-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 312.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.321±0.06 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• PKA: 12.99±0.70(Predicted)
• CAS DataBase Reference: tert-Butyl 4-bromo-3,5-dimethylphenylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 4-bromo-3,5-dimethylphenylcarbamate(361436-27-3)
• EPA Substance Registry System: tert-Butyl 4-bromo-3,5-dimethylphenylcarbamate(361436-27-3)

Safety Data

• Hazardous Substances Data: 361436-27-3(Hazardous Substances Data)

Upstream product

• 59557-90-3 4-bromo-3,5-dimethylaniline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7463-51-6 4-bromo-3,5-dimethylphenol 

Downstream Products

• 361435-55-4 (4-{[1-(tert-butyl-dimethyl-silanyl)-3-isopropyl-1H-indol-5-yl]-hydroxy-methyl}-3,5-dimethyl-phenyl)-carbamic acid tert-butyl ester 
• 374713-28-7 tert-butyl 4-[[3-(4-fluorobenzyl)-4-methoxyphenyl](hydroxy)methyl]-3,5-dimethylphenylcarbamate 
• 374713-23-2 tert-butyl 4-[hydroxy(4-methoxy-3-isopropylphenyl)methyl]-3,5-dimethylphenylcarbamate 

Relevant articles and documents

Economical and Readily Accessible Preparation of o,o-Disubstituted Arylboronates through Palladium-Catalyzed Borylation of Haloarenes

Miyaura borylation, that is, palladium-catalyzed cross-coupling between bromoarenes and diboron, offers a versatile method for preparing arylboronates; however, a costly and inaccessible catalyst has been required for synthesizing highly congested arylboronates with the method. Here the Pd(OAc)2–tri(4-methoxyphenyl)phosphine catalyst was found to work as an efficient catalyst for the sterically demanding borylation. A broad range of o,o-disubstituted bromoarenes were converted into the corresponding arylboronates in high yields by using the palladium catalyst with Cs2CO3 in EtOAc at 80 °C.