361440-89-3Relevant articles and documents
Stereochemistry of new nitrogen containing heterocyclic aldehyde. VII. Potentiometric, conductometric and thermodynamic studies of novel quinoline azodyes and their metal complexes with some transition metals
El-Sonbati,El-Bindary,Shoair,Younes
, p. 1308 - 1313 (2001)
A novel series of quinoline azodyes (5-(4′-derivatives phenyldiazo)-8-hydroxy-7-quinolinecarboxaldehyde) (HL1-HL5) has been prepared and characterized by elemental analyses, 1H-NMR and IR spectra. The IR spectral data indicate that the compounds can exist in two resonance structures. Proton-ligand dissociation constants of quinoline azodyes and their subsituted derivatives, and metal-ligand stability constants of their complexes with bivalent (Mn2+, Co2+, Ni2+, Cu2+) metal ions have been determined potentiometrically in 0.1 M KCl and 40% (v/v) dimethylformamide (DMF)-water mixture. The influence of substituents on the dissociation and stability constants was examined on the basis of the electron repelling property of the substituent. The order of the stability constants of the formed complexes was found to be Mn2+2+2+2+. The effect of temperature was studied and the corresponding thermodynamic parameters (ΔG, ΔH, ΔS) were derived and discussed. The stoichiometries of these complexes were determined conductometrically and indicated the formation of 1:1 and 1:2 (metal:ligand) complexes was indicated.
Synthesis, characterization, antimicrobial activity and ultrastructure of the affected bacteria of new quinoline compounds
El-Sonbati,Abou-Dobara,Diab,El-Bindary,Nozha
, p. 6449 - 6481 (2016/07/06)
The reaction on 8-hydroxy quinoline-7-aldehyde azo compounds (HLn) (where n?=?1–5) with 4-amino-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one to obtain HLn (where n?=?6–10) have been characterized by means of TLC, melting point and spectral data, such as IR, 1H NMR, mass spectra and thermal studies. The X-ray diffraction patterns of two starting materials 8-hydroxy quinoline-7-aldehyde (start 1), 4-amino-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one (start 2) and the ligands (HL5,10) are investigated in powder form. All the ligands have been screened for their antimicrobial activity against four local bacterial species, two Gram-positive bacteria (Bacillus cereus and Staphylococcus aureus) and two Gram-negative bacteria (Escherichia coli and Klebsiella pneumoniae) as well as against four local fungi; Aspergillus niger, Alternaria alternata, Penicillium italicum and Fusarium oxysporium. The results show that the azo ligands (HLn) (where n?=?1–5) have no antimicrobial activity against bacteria and fungi while most azomethine ligands (HLn) (where n?=?6–10) are good antibacterial agents against E. coli and K. pneumoniae as well as antifungal agents against P. italicum and A. alternata. The results were compared to standard substances (start 1) and (start 2). Among the azomethine ligands, HL10 was the most effective against the most microorganisms tested. The size of clear zone was ordered as p-(OCH3?3?2) as expected from Hammett’s constant (σR). Also, the ultrastructure study of the affected bacteria confirmed that HL8 is good antibacterial agent against E. coli and S. aureus.
