361543-07-9 Usage
Description
Azido-PEG8-azide is an aqueous soluble, homobifunctional PEG reagent that features reactive azide (N3) groups. These groups readily participate in Click Chemistry reactions with alkynes, such as BCN and DBCO, to form stable triazole moieties.
Uses
Used in Bioconjugation Applications:
Azido-PEG8-azide is used as a bioconjugation agent for the attachment of biomolecules to other molecules or surfaces. The reactive azide groups facilitate the formation of stable triazole linkages through Click Chemistry, enabling the precise and efficient conjugation of various entities.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Azido-PEG8-azide is used as a component in drug delivery systems. Its ability to form stable triazole moieties through Click Chemistry allows for the development of targeted and controlled release drug formulations, improving the therapeutic efficacy and reducing side effects.
Used in Materials Science:
Azido-PEG8-azide is utilized as a building block in the synthesis of functional materials. The reactivity of the azide groups allows for the creation of novel materials with tailored properties, such as self-healing polymers, hydrogels, and stimuli-responsive materials, through Click Chemistry techniques.
Used in Chemical Biology:
In chemical biology research, Azido-PEG8-azide is employed as a tool for the study of biological systems. The formation of stable triazole moieties through Click Chemistry enables the exploration of protein-protein interactions, enzyme activity, and cellular processes, providing valuable insights into the underlying mechanisms of various biological phenomena.
Check Digit Verification of cas no
The CAS Registry Mumber 361543-07-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,1,5,4 and 3 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 361543-07:
(8*3)+(7*6)+(6*1)+(5*5)+(4*4)+(3*3)+(2*0)+(1*7)=129
129 % 10 = 9
So 361543-07-9 is a valid CAS Registry Number.
361543-07-9Relevant articles and documents
Synthesis and analysis of polyethylene glycol linked P-glycoprotein-specific homodimers based on (-)-stipiamide
Andrus, Merritt B.,Turner, Timothy M.,Updegraff, Emily P.,Sauna, Zuben E.,Ambudkar, Suresh V.
, p. 3819 - 3822 (2007/10/03)
A series of five homodimeric polyethylene glycol (PEG) linked homodimers based on the multidrug resistance reversal agent (-)-stipiamide were made and tested for their ability to interact with P-glycoprotein, the protein responsible for multidrug resistance, using ATPase and photoaffinity displacement assays. Key reactions include a new alkoxide-mesylate displacement for the assembly of the PEG linkers and a double Sonogashira coupling reaction.
