36167-63-2

Basic information

• Product Name: Halofantrine hydrochloride
• Synonyms: Halofantarine HCL;Halfan, 1,3-Dichloro-a-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol hydrochloride;Halfan;D02485;Halfan (tn);Halofantrine hydrochloride (usan);Halfan Hydrochloride;9-PhenanthreneMethanol,1,3-dichloro-alpha-[2-(dibutylaMino)ethyl]-6-(trifluoroMethyl)-,hydrochloride (1:1)
• CAS NO: 36167-63-2
• Molecular Formula: C₂₆H₃₀Cl₂F₃NO*ClH
• Molecular Weight: 536.89
• EINECS: 252-895-4
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 36167-63-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 93-96°; mp 203-204°
• Boiling Point: 596.2°Cat760mmHg
• Flash Point: 314.4°C
• Appearance: white to off-white/
• Density: 1.244g/cm³
• Storage Temp.: 2-8°C
• Solubility: DMSO: >10mg/mL
• CAS DataBase Reference: Halofantrine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Halofantrine hydrochloride(36167-63-2)
• EPA Substance Registry System: Halofantrine hydrochloride(36167-63-2)

Safety Data

• WGK Germany: 3
• RTECS: SF7790000
• Hazardous Substances Data: 36167-63-2(Hazardous Substances Data)

Usage

Description

Halofantrine hydrochloride is a synthetic antimalarial drug that belongs to the class of phenanthrenemethanols. It is characterized by its ability to effectively combat chloroquine-resistant malaria strains, making it a valuable treatment option for individuals in regions where traditional antimalarial drugs are no longer effective.

Uses

Used in Antimalarial Applications:
Halofantrine hydrochloride is used as an antimalarial agent for treating chloroquine-resistant malaria infections. It is particularly effective against the Plasmodium falciparum parasite, which is responsible for the most severe cases of malaria. The drug works by disrupting the parasite's ability to reproduce and survive within the host's red blood cells, thereby reducing the severity and duration of the illness.
Used in African Regions:
Halofantrine hydrochloride is being evaluated in Africa as a potential solution to the growing problem of chloroquine-resistant malaria. The drug's effectiveness in treating resistant strains of the Plasmodium falciparum parasite makes it a promising candidate for widespread use in regions where malaria is endemic and traditional treatments are no longer sufficient. This evaluation aims to determine the safety, efficacy, and potential benefits of incorporating halofantrine hydrochloride into the standard treatment protocols for malaria in Africa.

InChI:InChI=1/C26H32Cl2F3NO.ClH/c1-3-5-12-32(13-6-4-2)14-11-24(33)25(28)17-20(27)16-22-21-15-19(26(29,30)31)9-7-18(21)8-10-23(22)25;/h7-10,15-16,24,33H,3-6,11-14,17H2,1-2H3;1H

Relevant articles and documents

Preparation method of halofantrine hydrochloride

The invention provides a preparation method of halofantrine hydrochloride. The method comprises the following steps: generating corresponding acyl chloride from 4-trifluoromethyl-2-(3, 5-dichlorophenyl) phenylacetic acid and an acylating chlorination reagent, carrying out Friedel-Crafts reaction cyclization, performing condensation with N, N-di-n-butyl-beta-aminopropionate, and finally, carrying out reduction, aromatization and salification to obtain the halofantralin hydrochloride. The method has the advantages of cheap and accessible raw materials and low cost; reaction conditions are easy to realize, the technological process and operation are safe, simple and convenient, less wastewater is generated, and environmental friendliness is achieved; and the intermediate is good in stability,the reaction activity and selectivity are high, there are fewer side reactions, and the prepared halofantrine hydrochloride is few in impurity, high in purity and high in yield.