362-03-8

Basic information

• Product Name: 10-Phenothiazine propiocic acid
• Synonyms: 10-Phenothiazine propiocic acid;10H-Phenothiazine-10-propanoic acid;10H-Phenothiazine-10-propionic acid;3-(10H-Phenothiazine-10-yl)propionic acid;Phenothiazine-10-propionic Acid;3-(10-Phenothiazin-10-yl)propionic Acid;3-(Phenothiazin-10-yl)propanoic Acid;NSC 525721
• CAS NO: 362-03-8
• Molecular Formula: C₁₅H₁₃NO₂S
• Molecular Weight: 271.34
• EINECS: 421-260-5
• Product Categories: Aroamtics;Heterocycles;Intermediates;Sulfur & Selenium Compounds
• Mol File: 362-03-8.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 477°Cat760mmHg
• Flash Point: 242.3°C
• Appearance: /
• Density: 1.321g/cm³
• Vapor Pressure: 6.62E-10mmHg at 25°C
• Solubility: Ethyl Acetate, Methanol, Water
• CAS DataBase Reference: 10-Phenothiazine propiocic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 10-Phenothiazine propiocic acid(362-03-8)
• EPA Substance Registry System: 10-Phenothiazine propiocic acid(362-03-8)

Safety Data

• Hazard Codes: N
• Statements: 51/53
• Safety Statements: 24/25-61
• HazardClass: IRRITANT
• Hazardous Substances Data: 362-03-8(Hazardous Substances Data)

Usage

Description

10-Phenothiazine propiocic acid is an organic compound derived from Phenothiazine, characterized by its red solid appearance. It is known for its chemical properties and potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
10-Phenothiazine propiocic acid is used as a reagent for the addition of Phenothiazine (P318040), a compound with significant applications in the pharmaceutical industry. Its role in the synthesis of Phenothiazine-based drugs makes it a valuable component in drug development and production.
Used in Chemical Synthesis:
10-Phenothiazine propiocic acid is utilized as a reagent in the chemical synthesis of various compounds, particularly those involving Phenothiazine. Its unique chemical properties allow it to contribute to the formation of new molecules with potential applications in different fields.
Used in Research and Development:
In the realm of research and development, 10-Phenothiazine propiocic acid serves as a key compound for exploring the properties and potential applications of Phenothiazine and its derivatives. Its use in this context aids in advancing scientific knowledge and the discovery of new compounds with beneficial properties.

InChI:InChI=1/C15H13NO2S/c17-15(18)9-10-16-11-5-1-3-7-13(11)19-14-8-4-2-6-12(14)16/h1-8H,9-10H2,(H,17,18)/p-1

Upstream product

• 1698-80-2 10H-phenothiazine-10-propanenitrile 
• 107943-89-5 β-(10-Phenothiazyl)propionic acid ethyl ester 
• 92-84-2 10H-phenothiazine 

Downstream Products

• 3023-04-9 3-phenothiazin-10-yl-N-(4-thiazol-2-ylsulfamoyl-phenyl)-propionamide 
• 2886-42-2 N-[4-(2,6-dimethyl-pyrimidin-4-ylsulfamoyl)-phenyl]-3-phenothiazin-10-yl-propionamide 
• 2886-41-1 N-[4-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-phenyl]-3-phenothiazin-10-yl-propionamide 
• 7045-65-0 tetra-O-benzoyl-2-(3-phenothiazin-10-yl-propionylamino)-β-D-2-deoxy-glucopyranose 
• 2765-58-4 3-phenothiazin-10-yl-N-(4-sulfamoyl-phenyl)-propionamide 
• 2889-05-6 N-(4-carbamimidoylsulfamoyl-phenyl)-3-phenothiazin-10-yl-propionamide 
• 2889-04-5 N-(4-acetylsulfamoyl-phenyl)-3-phenothiazin-10-yl-propionamide 
• 5909-59-1 10-(3-chloropropyl)-10H-phenothiazine 

Relevant articles and documents

Electrochemical primer extension for the detection of single nucleotide polymorphisms in the cardiomyopathy associated MYH7 gene

We report the labelling of dideoxy nucleotides (ddNTPs) for use in electrochemical array based primer extension for the detection of single nucleotide polymorphisms (SNPs). The results confirm the extension of the immobilised primers for each of the four ddNTPs, representing a significant advance in achieving a cost-effective platform for screening of disease-specific SNPs.

Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds

A new family of CaaX competitive inhibitors of human farnesyltransferase based on phenothiazine and carbazole skeleton bearing a l-cysteine, l-methionine, l-serine or l-valine moiety was designed, synthesized and biologically evaluated. Phenothiazine derivatives proved to be more active than carbazole-based compounds. Phenothiazine 1b with cysteine residue was the most promising inhibitor of human farnesyltransferase in the current study.

Peptide chemistry applied to a new family of phenothiazine-containing inhibitors of human farnesyltransferase

Novel phenothiazine derivatives bearing an amino acid residue were synthesized via peptide chemistry, and evaluated for their inhibitory potential on human farnesyltransferase. The phenothiazine unit proved to be an important bulky unit in the structure o