362-86-7

Basic information

• Product Name: 3-(p-fluorophenyl)-3-phenylpropionic acid
• Synonyms: 3-(p-fluorophenyl)-3-phenylpropionic acid;4-Fluoro-β-phenylbenzenepropionic acid;3-(4-fluorophenyl)-3-phenylpropanoic acid(SALTDATA: FREE);3-(4-Fluorophenyl)-3-phenylpropanoic acid
• CAS NO: 362-86-7
• Molecular Formula: C₁₅H₁₃FO₂
• Molecular Weight: 244.2609232
• EINECS: 206-652-4
• Mol File: 362-86-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 359.8°Cat760mmHg
• Flash Point: 171.4°C
• Appearance: /
• Density: 1.212g/cm³
• Vapor Pressure: 8.35E-06mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: 3-(p-fluorophenyl)-3-phenylpropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(p-fluorophenyl)-3-phenylpropionic acid(362-86-7)
• EPA Substance Registry System: 3-(p-fluorophenyl)-3-phenylpropionic acid(362-86-7)

Safety Data

• Hazardous Substances Data: 362-86-7(Hazardous Substances Data)

Usage

General Description

3-(p-fluorophenyl)-3-phenylpropionic acid, also known as flurbiprofen, is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used for its analgesic and anti-inflammatory properties. It works by inhibiting the production of prostaglandins, which are chemicals in the body that cause pain and inflammation. Flurbiprofen is often used to treat conditions such as arthritis, menstrual cramps, and other types of pain. It is available in both prescription and over-the-counter forms, and is generally well tolerated when used as directed, although it may cause side effects such as gastrointestinal discomfort and increased risk of cardiovascular events with prolonged use. It is important to use flurbiprofen as directed and to consult a healthcare professional before using it, especially if you have any underlying health conditions or are taking other medications.

InChI:InChI=1/C15H13FO2/c16-13-8-6-12(7-9-13)14(10-15(17)18)11-4-2-1-3-5-11/h1-9,14H,10H2,(H,17,18)

Upstream product

• 462-06-6 fluorobenzene 
• 140-10-3 (E)-3-phenylacrylic acid 
• 390-42-1 (E/Z)-3-(4-fluorophenyl)-3-phenylpropenoic acid 
• 365-21-9 1-(chlorophenylmethyl)-4-fluorobenzene 
• 2025-40-3 ethyl benzylidenecyanoacetate 
• 100-52-7 benzaldehyde 
• 395-21-1 1-(4-fluorophenyl)-1-phenylethylene 
• 19334-70-4 3-Hydroxy-3-phenyl-3-<4-fluor-phenyl>-propionsaeure 
• 428-00-2 3-(4-fluoro-phenyl)-3-hydroxy-3-phenyl-propionic acid ethyl ester 
• 621-82-9 Cinnamic acid 
• 459-32-5 4-fluorocinnamic acid 
• 98-80-6 phenylboronic acid 
• 1765-93-1 4-fluoroboronic acid 
• 3495-36-1 cesium formate 

Downstream Products

• 85662-85-7 3-(4-fluorophenyl)-2,3-dihydro-1H-indene-1-one 
• 374724-94-4 3-(4-fluorophenyl)-3-phenylpropan-1-ol 
• 1026728-00-6 2-(2-{2-[3-(4-fluoro-phenyl)-3-phenyl-propyl]-1H-imidazol-4-yl}-ethyl)-isoindole-1,3-dione 
• 80272-55-5 cis-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-ol 
• 104087-10-7 1-chloro-4-(4-flurophenyl)indan 
• 80273-08-1 Lu 17-123 

Relevant articles and documents

Photoredox Activation of Formate Salts: Hydrocarboxylation of Alkenes via Carboxyl Group Transfer

A photoredox activation mode of formate salts for carboxylation was developed. Using a formate salt as the reductant, carbonyl source, and hydrogen atom transfer reagent, a wide range of alkenes can be converted into acid products via a carboxyl group tra

Synthesis method of succinic acid derivative or 3 -arylpropionic acid (by machine translation)

The invention discloses a synthesis method of a succinic acid derivative or 3 -arylpropionic acid, which comprises the following steps: adding a base in a drying reaction tube and CO removing CO. 2 The reaction is carried out under the irradiation of visible light, the reaction is carried out under visible light irradiation, and then separation and purification are carried out to obtain the butanedioic acid derivative or 3 -arylpropionic acid product; the base comprises sodium tert-butoxide, potassium tert-butoxide, lithium tert-butyl alcohol and 4 - potassium carbonate; and the reaction substrate comprises an acrylate compound or an aryl vinyl compound. CO can be induced by visible light. 2 The scheme provided by the invention is mild in reaction condition and wide in reaction 3 - substrate selectivity, and the reaction substrate is wide in selectivity, the raw materials are cheap and easily available, and the method has a good industrial application prospect. (by machine translation)

Pd(II)/Bipyridine-Catalyzed Conjugate Addition of Arylboronic Acids to α,β-Unsaturated Carboxylic Acids. Synthesis of β-Quaternary Carbons Substituted Carboxylic Acids

Pd(II)/bipyridine-catalyzed conjugate addition of arylboronic acids to α,β-unsaturated carboxylic acids (including β,β-disubstituted acrylic acids) was developed and optimized, which provided a mild and convenient method for the highly challenging synthesis of β-quaternary carbons substituted carboxylic acids.