362049-55-6 Usage
Description
D-PHENYL-D5-ALANINE, also known as D-Phenylalanine-d5, is a deuterated amino acid derivative of Phenylalanine. It is characterized by the presence of five deuterium atoms, which makes it a stable isotope-labeled compound. This unique property allows for its use in various analytical and synthetic applications.
Uses
Used in Mass Spectrometry:
D-PHENYL-D5-ALANINE is used as an internal standard for the quantification of Phenylalanine by GCor LC-mass spectrometry. The incorporation of deuterium atoms in D-PHENYL-D5-ALANINE provides a distinct mass difference compared to the natural Phenylalanine, enabling accurate quantification and differentiation between the two compounds in complex biological samples.
Used in Pharmaceutical Synthesis:
D-PHENYL-D5-ALANINE is used as a building block in the synthesis of Schaeffer's acid analogues, which are important structures in the design of tuberculostatic drugs. These analogues exhibit the ability to inhibit Mycobacterium tuberculosis type II dehydroquinase, a key enzyme in the bacterial metabolism. The use of D-PHENYL-D5-ALANINE in this context allows for the development of more effective and targeted treatments against tuberculosis.
Check Digit Verification of cas no
The CAS Registry Mumber 362049-55-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,2,0,4 and 9 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 362049-55:
(8*3)+(7*6)+(6*2)+(5*0)+(4*4)+(3*9)+(2*5)+(1*5)=136
136 % 10 = 6
So 362049-55-6 is a valid CAS Registry Number.
362049-55-6Relevant articles and documents
Preparation of Deuterium Labeled Compounds by Pd/C-Al-D2O Facilitated Selective H-D Exchange Reactions
Kadish, Dora,Kokel, Anne,T?r?k, Béla
supporting information, (2022/01/24)
The chemo/regioselective H-D exchange of amino acids and synthetic building blocks by an environmentally benign Pd/C-Al-D2O catalytic system is described. Due to the importance of isotope labeled compounds in medicinal chemistry and structural biology, no
Determination of molecular torsion angles using nuclear singlet relaxation
Tayler, Michael C. D.,Marie, Sabrina,Ganesan,Levitt, Malcolm H.
supporting information; experimental part, p. 8225 - 8227 (2010/08/05)
The exponential relaxation time constant, TS , of a nuclear singlet state is influenced by the proximity of neighboring NMR-active nuclei. For methylene groups in particular this dependence is much stronger than the case for other NMR relaxation constants, including the conventional relaxation time constant, T1 , of the longitudinal magnetization. This sensitivity provides a new route for determining torsional angles plus other molecular structural details in the isotropic solution phase.
PROPERTIES OF AROMATIC RESIDUES IN FERRICYTOCHROME c3 OF DESULFOVIBRIO VULGARIS MIYAZAKI F STUDIED BY 1H NMR
Park, Jang-Su,Enoki, Minoru,Ohbu, Ayako,Fan, Kejung,Niki, Katsumi,et al.
, p. 343 - 353 (2007/10/02)
Conditions for the specific labelling of the tetrahaeme protein cytochrome c3 of Desulfovibrio vulgaris Miyazaki F during culture of this sulphate-reducing bacterium in a medium were established.Phenylalanine and tyrosine residues were specific
