362052-00-4

Basic information

• Product Name: 2-(4-Cyanophenyl)propanoic acid
• Synonyms: 2-(4-Cyanophenyl)propanoic acid
• CAS NO: 362052-00-4
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18396
• Mol File: 362052-00-4.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(4-Cyanophenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Cyanophenyl)propanoic acid(362052-00-4)
• EPA Substance Registry System: 2-(4-Cyanophenyl)propanoic acid(362052-00-4)

Safety Data

• Hazardous Substances Data: 362052-00-4(Hazardous Substances Data)

Usage

General Description

2-(4-Cyanophenyl)propanoic acid is a chemical compound with the molecular formula C10H9NO2. It is a derivative of propanoic acid and contains a cyanophenyl group as a substituent. 2-(4-Cyanophenyl)propanoic acid is a white solid at room temperature and is sparingly soluble in water. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. The compound has potential applications in the treatment of inflammation and pain, as well as in the development of new drugs. Its chemical structure and properties make it a valuable building block for the production of a wide range of organic compounds.

Upstream product

• 125670-62-4 α-methyl-4-cyanobenzeneacetic acid methyl ester 
• 3435-51-6 4-ethenylbenzonitrile 
• 124-38-9 carbon dioxide 
• 1253037-62-5 1-(p-cyanophenyl)ethyl methyl carbonate 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 14062-25-0 Ethyl 4-bromophenylacetate 
• 118618-32-9 ethyl 2-(p-cyano-phenyl)-propionate 
• 1528-41-2 ethyl 4-cyanophenylacetate 
• 20488-11-3 4-(1-chloroethyl)benzonitrile 
• 101219-69-6 4-(1-hydroxyethyl)benzonitrile 
• 201230-82-2 carbon monoxide 
• 4187-31-9 4-(1-dimethylamino-ethyl)-benzonitrile 

Downstream Products

• 331766-54-2 N-{2-[2-(4-Cyanophenyl)-ethyl]-1-(3,5-bis-trifluoromethyl-benzyl)-benzimidazol-5-yl}-benzenesulphonamide 
• 125670-62-4 α-methyl-4-cyanobenzeneacetic acid methyl ester 
• 1428790-18-4 2-(4-(aminomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428765-47-2 2-(4-(aminomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428765-46-1 2-(4-cyanophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428765-05-2 2-(4-((sulfamoylamino)methyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428765-48-3 tert-butyl N-(4-(1-oxo-1-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzyl)sulfamoylcarbamate 
• 1428790-17-3 2-(4-cyanophenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428789-44-9 2-(4-(methylsulfonamidomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 

Relevant articles and documents

Preparation method of organic carboxylic acid

The invention discloses a preparation method of organic carboxylic acid. The preparation method comprises the following steps that catalysts, olefins, water and solvents are added into a reaction container; CO is introduced; heating reaction is performed; after the reaction completion, separation is performed to obtain organic carboxylic acid; the catalysts comprise transition metal catalysts, ligands and catalysis assistants; the catalysis assistants comprise Lewis acid salt. The preparation method has the advantages that the dependency on protonic acid in the prior art is avoided; the Lewisacid salt is used as the catalysis assistant, so that the corrosion of a reaction system on equipment can be effectively prevented; the requirements on equipment are lowered. The preparation method has excellent substrate practicability; the operation steps are simple and fast; the reaction conditions are mild and are easy to control; the raw materials are cheap and can be easily obtained; the product yield and the product purity are high; the preparation method is suitable for large-scale industrial production; the normal/iso ratio of reaction products can be regulated and controlled throughthe catalysis assistants; the defects of regulating and controlling the normal/iso ratio of the reaction products by traditional phosphine ligands are overcome; the reaction progress of the reaction is simplified; the cost is favorably reduced.

Regioselectivity inversion tuned by iron(iii) salts in palladium-catalyzed carbonylations

Impactful regioselectivity control is crucial for cost-effective chemical synthesis. By using cheap and abundant iron(iii) salts, the hydroxycarbonylations of both aromatic and aliphatic alkenes were significantly enhanced in both reactivity and selectivity (iso/n or n/iso up to >99:1). Moreover, Pd-catalyzed carbonylation selectivity can be switched from branched to linear by using different Fe(iii) salts. In addition, similar results were obtained for the carbonylation of secondary alcohols.

Construction of a visible light-driven hydrocarboxylation cycle of alkenes by the combined use of Rh(i) and photoredox catalysts

A visible light driven catalytic cycle for hydrocarboxylation of alkenes with CO2 was established using a combination of a Rh(i) complex as a carboxylation catalyst and [Ru(bpy)3]2+ (bpy = 2,2′- bipyridyl) as a photoredox catalyst. Two key steps, the generation of Rh(i) hydride species and nucleophilic addition of π-benzyl Rh(i) species to CO2, were found to be mediated by light.