36216-80-5 Usage
Description
3-Amino-1,2-benzisoxazole is an organic compound that belongs to the class of isoxazoles, characterized by a fused benzene and isoxazole ring system. It is a white to light brown solid and is known for its chemical reactivity and potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
3-Amino-1,2-benzisoxazole is used as a reagent for the preparation of benzisoxazole sulfonamides, which are valuable compounds in the treatment of various diseases. These sulfonamides have demonstrated potential therapeutic properties, making them an important class of compounds in the development of new drugs.
Used in Chemical Synthesis:
Due to its unique chemical structure, 3-Amino-1,2-benzisoxazole can be employed as a building block in the synthesis of more complex organic molecules. Its reactivity and versatility make it a valuable intermediate in the development of novel compounds for various applications, including pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
3-Amino-1,2-benzisoxazole serves as an important research tool in the field of organic chemistry. It is used to study the properties and reactivity of isoxazole-containing compounds, as well as to explore new synthetic routes and methodologies. This knowledge can be applied to the development of new drugs, materials, and other useful compounds.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 26, p. 1293, 1989 DOI: 10.1002/jhet.5570260515
Check Digit Verification of cas no
The CAS Registry Mumber 36216-80-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,2,1 and 6 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 36216-80:
(7*3)+(6*6)+(5*2)+(4*1)+(3*6)+(2*8)+(1*0)=105
105 % 10 = 5
So 36216-80-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H6N2O/c8-7-5-3-1-2-4-6(5)10-9-7/h1-4H,(H2,8,9)
36216-80-5Relevant articles and documents
Application of a recyclable fluorous oxime in the convenient synthesis of 3-amino-1,2-benzisoxazoles and 4-amino-1H-2,3-benzoxazines
Ang, Wei Jie,Chu, Chi-Yuan,Chou, Tzyy-Chao,Lo, Lee-Chiang,Lam, Yulin
, p. 780 - 785 (2013/04/10)
A microwave-assisted, fluorous synthetic route to 3-amino-1,2- benzisoxazoles and 4-amino-1H-2,3-benzoxazines has been developed. The strategy comprises linking the respective 2-fluorobenzonitrile or 2-(bromomethyl) benzonitrile to a fluorous oxime tag to give an aryloxime intermediate which then undergoes cyclization with concomitant cleavage of the substrate-tag in acidic conditions to provide the desired product in good to moderate yields. In addition, the aryloxime intermediate could be subjected to further reactions to expand the compound library. The product could be easily separated using fluorous solid-phase extraction (F-SPE) and the fluorous ketone recovered could be converted back to the fluorous oxime and reused in the next run of the synthesis.
