36245-26-8

Basic information

• Product Name: 2-(4-phenylpiperazin-1-yl)ethanol
• Synonyms: 1-piperazineethanol, 4-phenyl-
• CAS NO: 36245-26-8
• Molecular Formula: C₁₂H₁₈N₂O
• Molecular Weight: 206.2841
• Mol File: 36245-26-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 353.6°C at 760 mmHg
• Flash Point: 180.2°C
• Density: 1.098g/cm³
• Vapor Pressure: 1.3E-05mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 2-(4-phenylpiperazin-1-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-phenylpiperazin-1-yl)ethanol(36245-26-8)
• EPA Substance Registry System: 2-(4-phenylpiperazin-1-yl)ethanol(36245-26-8)

Safety Data

• Hazardous Substances Data: 36245-26-8(Hazardous Substances Data)

Usage

Psychoactive properties

PAPP-E is a psychoactive compound derived from piperazine, meaning it can affect the central nervous system and alter mental state.

Abuse potential and addiction

PAPP-E is known to have abuse potential and can be addictive, leading to its classification as a controlled substance in many countries.

Upstream product

• 141-43-5 ethanolamine 
• 92-54-6 4-phenyl-1-piperazine 
• 107-07-3 2-chloro-ethanol 
• 102-71-6 triethanolamine 
• 7664-93-9 sulfuric acid 
• 62-53-3 aniline 
• 56968-26-4 ethyl 2-(4-phenyl-piperarazin-1-yl)acetate 
• 75-21-8 oxirane 

Downstream Products

• 72223-82-6 2-(4-phenylpiperazin-1-yl)ethyl methanesulfonate 
• 43219-09-6 1-(2-chloroethyl)-4-phenylpiperazine 
• 17419-72-6 1,2-bis-(4-phenyl-piperazino)-ethane 
• 127227-51-4 4-[2-(4-Phenyl-piperazin-1-yl)-ethoxy]-benzaldehyde; hydrochloride 
• 127227-52-5 1-[2-(4-Bromo-phenoxy)-ethyl]-4-phenyl-piperazine; hydrochloride 
• 77627-67-9 1-(4-nitrophenoxy)-2-1-(N⁴-phenylpiperazinyl)>ethane 
• 90096-02-9 3-methyl 5-[2-(4-phenyl-1-piperazinyl)-ethyl] (+)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate 
• 90096-03-0 methyl 2-(4-phenyl-1-piperazinyl)ethyl 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant articles and documents

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synthesis and structure activity relationship in aryloxyalkylamines

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N-Aryl-N-phenoxy-alkyl-piperazine compounds useful in decreasing intracranial pressure

A piperazine derivative of the formula: STR1 wherein R1 is hydrogen, alkyl (C1-8), alkyl (C1-4)-sulfonyl or an acyl group of the formula: R3 CO--(wherein R3 is hydrogen, alkyl (C1-7), halogenoalkyl (C1-4), alkoxy (C1-4)-carbonyl-alkyl (C1-4), cycloalkyl (C3-6), alkenyl (C2-5), alkoxy (C1-4), amino, alkyl (C1-4)-amino or anilino), R2 is hydrogen, alkyl (C1-4), alkoxy (C1-4)-carbonyl-alkyl (C1-4), carboxy-alkyl (C1-4), alkenyl (C2-5) or alkyl (C1-4)-sulfonyl, or R1 and R2 are combined together to form succinyl group, Ring A is phenyl, alkyl (C1-4)-phenyl or halogenophenyl, and n is an integer of 2 to 6, or a pharmaceutically acceptable acid addition salt thereof. The piperazine derivative (I) has an intracranial pressure-lowering activity. Said derivative also has a depressing effect on central nervous system.