362524-23-0 Usage
Description
(R)-(+)-2,2',6,6'-TETRAMETHOXY-4,4'-BIS(DIPHENYLPHOSPHINO)-3,3'-BIPYRIDINE, also known as (S)-P-Phos, is a chiral phosphine ligand with a unique structure that features two diphenylphosphino groups connected to a bipyridine core through methoxy substituents. This ligand is characterized by its strong electron-donating ability and its ability to form stable complexes with various metal catalysts.
Uses
Used in Asymmetric Hydrogenation Reactions:
(R)-(+)-2,2',6,6'-TETRAMETHOXY-4,4'-BIS(DIPHENYLPHOSPHINO)-3,3'-BIPYRIDINE is used as a ligand in asymmetric hydrogenation reactions, where it plays a crucial role in enhancing the enantioselectivity and reactivity of the reaction. Its strong electron-donating ability and steric properties enable the formation of stable and active metal complexes, leading to the production of chiral compounds with high enantiomeric excess.
Used in the Preparation of Chiral Ketone Functionalized Polymers:
In the polymer industry, (R)-(+)-2,2',6,6'-TETRAMETHOXY-4,4'-BIS(DIPHENYLPHOSPHINO)-3,3'-BIPYRIDINE is used as a ligand for the preparation of chiral ketone functionalized polymers through copolymerization reactions. The incorporation of chiral ketone groups into the polymer backbone imparts unique properties, such as enhanced chiral recognition and improved self-assembly behavior, making these polymers suitable for various applications, including chiral separation and sensing.
Used in the Synthesis of Chiral Alkynes:
(R)-(+)-2,2',6,6'-TETRAMETHOXY-4,4'-BIS(DIPHENYLPHOSPHINO)-3,3'-BIPYRIDINE is used as a ligand in the synthesis of chiral alkynes through asymmetric hydroalkynylation of nonpolar alkenes or norbornadienes using iridium catalysts. The ligand's strong electron-donating ability and steric properties enable the formation of highly enantioselective and reactive metal complexes, leading to the production of chiral alkynes with high enantiomeric excess. These chiral alkynes are valuable building blocks in the synthesis of various pharmaceuticals, agrochemicals, and natural products.
Used in the Selective Allylic Alkylation of Indoles:
In the pharmaceutical industry, (R)-(+)-2,2',6,6'-TETRAMETHOXY-4,4'-BIS(DIPHENYLPHOSPHINO)-3,3'-BIPYRIDINE is used as a ligand in the selective allylic alkylation of indoles using palladium catalysts. This reaction is an important method for the synthesis of biologically active indole-containing compounds, such as alkaloids and pharmaceuticals. The use of (R)-(+)-2,2',6,6'-TETRAMETHOXY-4,4'-BIS(DIPHENYLPHOSPHINO)-3,3'-BIPYRIDINE as a ligand enhances the selectivity and reactivity of the reaction, allowing for the efficient synthesis of chiral indole derivatives with high enantiomeric purity.
Reaction
New class of highly effective chiral dipyridylphosphine ligands used in the asymmetric hydrogenation of 2-arylacrylic acids, β-ketoesters, and aryl ketones.
Check Digit Verification of cas no
The CAS Registry Mumber 362524-23-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,2,5,2 and 4 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 362524-23:
(8*3)+(7*6)+(6*2)+(5*5)+(4*2)+(3*4)+(2*2)+(1*3)=130
130 % 10 = 0
So 362524-23-0 is a valid CAS Registry Number.
