3626-00-4Relevant articles and documents
Design and synthesis of the G-quadruplex-specific cleaving reagent perylene-EDTA·iron(II) [16]
Tuntiwechapikul,Jeong Tae Lee,Salazar
, p. 5606 - 5607 (2001)
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Synthesis of monomeric acridine derived nucleic acid intercalators
Csuk, René,Raschke, Christian,G?the, Gunnar,Rei?mann, Stefan
, p. 83 - 88 (2005)
A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA-derived conjugate was synthesized in an easy sequence. In the presence of ascorbate a reduction of the phage-titer of MS2 phages by several logarithmic decades was achieved.
Synthesis of pathogen inactivating nucleic acid intercalators
Csuk, René,Barthel, Alexander,Brezesinski, Thorsten,Raschke, Christian
, p. 975 - 988 (2007/10/03)
A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA-derived conjugate was synthesized in an easy sequence starting from 1,ω-alkyldiamines. As shown in model screenings, in the presence of ascorbic acid the Fe-complexes of these compounds reduced the phage-titer of MS2-phages by several logarithmic decades.