36288-91-2

Basic information

• Product Name: N,N’?(ethane?1,2?diyl)bis(phenylacetamide)
• Synonyms: N,N’?(ethane?1,2?diyl)bis(phenylacetamide)
• CAS NO: 36288-91-2
• Molecular Weight: 296.369
• Mol File: 36288-91-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N,N’?(ethane?1,2?diyl)bis(phenylacetamide)(CAS DataBase Reference)
• NIST Chemistry Reference: N,N’?(ethane?1,2?diyl)bis(phenylacetamide)(36288-91-2)
• EPA Substance Registry System: N,N’?(ethane?1,2?diyl)bis(phenylacetamide)(36288-91-2)

Safety Data

• Hazardous Substances Data: 36288-91-2(Hazardous Substances Data)

Upstream product

• 107-15-3 ethylenediamine 
• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 
• 23776-85-4 N-(phenylacetyl)oxysuccinimide 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 140-29-4 phenylacetonitrile 
• 103-81-1 Benzeneacetamide 

Relevant articles and documents

Synthesis, characterization, in vitro biological and molecular docking evaluation of N,N'-(ethane-1,2-diyl)bis(benzamides)

The present research describes the synthesis, characterization, in vitro biological and docking evaluation of N,N'-(ethane-1,2-diyl)bis(benzamides) (3a-3j). Consequently, in in vitro hRBCs hemolysis assay, only the bis-amide (3d) induced 52.4% hemolysis at higher concentration (1000?μg/mL) that decreased drastically with concentration (250?μg/mL) to 27.9% (CC50 = 400.41). Similarly, the tested bis-amide (3j) was found to be the least toxic with 7.8% hemolysis at higher concentration (1000?μg/mL) that gradually decreases to 6.1% (CC50 = 19,347.83) at lower concentration (250?μg/mL). Accordingly, the tested bis-amides were found to be highly biocompatible against hRBCs at higher concentrations with much higher CC50 values (> 1000?μg/mL). The biocompatible bis-amides (3a-3j) were subjected to in vitro DNA ladder assay to analyze their apoptotic potential. The results obtained suggest the tested bis-amides (3a-3j) are highly degradative toward DNA causing the appearance of more than one bands or complete degradation of DNA except (3a), (3c), (3i) and (3?g). Moreover, the synthesized bis-amides (3a-3j) were tested in in vitro antileishmanial assay to unveil their leishmaniacidal potential. The results obtained clearly indicated that some of the tested bis-amides displayed good dose dependent response. The tested bis-amides were highly active at higher concentration (1000?μg/mL) against the leishmanial promastigotes and their % inhibitory potential decreased drastically with concentration (250?μg/mL). Consequently, at higher concentration (1000?μg/mL), the bis-amide (3f) caused 85% inhibition and was ranked as the most effective leishmaniacidal bis-amides followed by the bis-amide (3?g) with 73.54% inhibition of leishmanial promastigotes. However, in terms of their IC50 values, the best leishmaniacidal potential was displayed by the bis-amide (3f) followed by (3b), (3j) and (3?g) with IC50 values increasing in the order of 633.16, 680.22, 680.22 and 712.93?μg/mL, respectively. Molecular docking studies revealed that bis-amides having electron-donating groups showed good binding potential against antileishmanial target. Graphic abstract: [Figure not available: see fulltext.].

Efficient and continuous monoacylation with superior selectivity of symmetrical diamines in microreactors

Efficient and continuous monoacylation of symmetrical diamines performed in microreactors yielded superior selectivity to that predicted by statistical considerations. It is highly valuable that the kinetically controlled product in high yields was achieved without any special catalyst at ambient temperature.