36296-97-6Relevant articles and documents
Amino alcohols using the optically active amino alcohol derivative bi- Nord complex boron - -
-
Paragraph 0064; 0071-0076; 0267-0269; 0271-0273, (2021/04/16)
Disclosed are an amino alcohol-boron-binol complex as an intermediate, including Complex 3-1-1 shown below, and a method for preparing an optically active amino alcohol by using the same, wherein a racemic amino alcohol is resolved in an enationselective manner using a boron compound and a (R)- or (S)-binol, whereby an amino alcohol derivative with high optical purity can be prepared at high yield.
Asymmetric hydrogenation of β-amino ketones with the bimetallic complex RuPHOX-Ru as the chiral catalyst
Wang, Jiahao,Liu, Delong,Liu, Yangang,Zhang, Wanbin
, p. 3855 - 3861 (2014/03/21)
Asymmetric hydrogenations of a series of β-amino ketones were carried out with a bimetallic complex (RuPHOX-Ru) as the chiral catalyst. Almost all the reactions (performed in a mixed solvent system of toluene and H2O in the presence of KOH) gave quantitative conversions into their respective products with up to 99.9% ee. The RuPHOX-Ru catalyst is stable to both moisture and air. The procedure has the benefits of being inexpensive, environmentally friendly and highly efficient. Under a relatively low catalyst loading (TON = 2000), key intermediates of fluoxetine, tomoxetine and nisoxetine could be obtained in quantitative yield and in up to 99.9% ee. This methodology represents a promising alternative to the synthesis of the aforementioned drugs and their analogues. This journal is The Royal Society of Chemistry 2013.
Asymmetric synthesis of α-N,N-dialkylamino alcohols by transfer hydrogenation of N,N-dialkylamino ketones
Kosmalski, Tomasz
experimental part, p. 717 - 721 (2011/05/14)
-
