363140-31-2Relevant articles and documents
SIGMA-2 RECEPTOR LIGAND DRUG CONJUGATES AS ANTITUMOR COMPOUNDS, METHODS OF SYNTHESIS AND USES THEREOF
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Paragraph 0151-0152, (2016/01/29)
Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds comprising a sigma-2 receptor-binding moiety and a ferroptosis-inducing moiety are described. At least one described molecular species exhibits an IC50 value below 5 μΜ against human pancreatic cancer cells in vitro. Administration of this species promoted shrinkage of pancreatic cancer tumors in a murine model system in vivo, and led to 100% survival of experimental animals over a time course in which control therapies provided only 30% or 40% survival. Methods of synthesis of molecular species are also disclosed.
Azabicyclo[3.2.1]octan-3α-yl and azabicyclo[3.3.1]nonan-3α-yl carbamates as σ2-selective radiotracers
Yang,Whirrett,Wu,Wheeler,Childers,Mach
, p. S684-S686 (2007/10/03)
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