363191-02-0

Basic information

• Product Name: 4-Piperidinecarboxamide, 4-cyclohexyl-N-(1,1-dimethylethyl)-
• CAS NO: 363191-02-0
• Molecular Formula: C16H30N2O
• Molecular Weight: 266.427
• Mol File: 363191-02-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-Piperidinecarboxamide, 4-cyclohexyl-N-(1,1-dimethylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidinecarboxamide, 4-cyclohexyl-N-(1,1-dimethylethyl)-(363191-02-0)
• EPA Substance Registry System: 4-Piperidinecarboxamide, 4-cyclohexyl-N-(1,1-dimethylethyl)-(363191-02-0)

Safety Data

• Hazardous Substances Data: 363191-02-0(Hazardous Substances Data)

Upstream product

• 674791-75-4 C₇H₈O₃S*C₁₂H₂₁NO₂ 
• 674791-76-5 1-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride 
• 852323-77-4 1-BOC-4-cyclohexyl-4-piperidinecarbonyl chloride 
• 273378-16-8 (1-tert-butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid 
• 167262-68-2 N-(t-butyloxycarbonyl)-4-phenylpiperidine-4-carboxylic acid 
• 852323-76-3 1-tert-butoxycarbonyl 4-tert-butylcarbamoyl-4-cyclohexylpiperidine 

Downstream Products

• 363192-59-0 (2R)-2-(BOC-amino)-N-[4-cyclohexyl-4-(t-butylcarbamoyl)piperidin-1-yl]-3-(4-chlorophenyl)propionamide 
• 1309060-04-5 C₃₂H₅₀ClN₅O₃ 
• 674792-27-9 fluoro-(D)-Phe,t-butyl amide dipeptide 
• 1309060-03-4 C₃₂H₅₀FN₅O₃ 
• 1309060-02-3 C₃₃H₅₂FN₅O₃ 
• 1225591-08-1 4-tert-butylcarbamoyl 4-cyclohexyl-1-[2-{3-[2-(1H-imidazol-4-yl)ethyl]ureido}-3-(4-methoxyphenyl)propionyl]-piperidine 
• 1362255-66-0 C₃₀H₄₈ClN₃O₃ 
• 1362244-39-0 C₂₄H₃₅FN₂O₂ 
• 363191-06-4 4-(2-tert-butoxycarbonylamino-propionyl)-2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 363189-17-7 2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-piperazine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester 
• 363189-18-8 (2S)-2-[[[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]amino]carbonyl]-1,4-piperazinedicarboxylic Acid 1-(1,1-dimethylethyl) 4-(phenylmethyl) Ester 
• 834888-51-6 2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-piperazine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester 
• 363190-30-1 2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-(2,2-difluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 363189-67-7 (S)-3-[(R)-2-(4-tert-Butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-methyl-piperazine-1-carboxylic acid benzyl ester 

Relevant articles and documents

MELANOCORTIN RECEPTOR ANTAGONIST COMPOUNDS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND COSMETICS

The present invention relates to novel melanocortin receptor antagonist compounds corresponding to the general formula (I) below, to compositions containing them, to the process for preparing them and to their use in pharmaceutical or cosmetic compositions.

Melanocortin subtype 4 receptor agonists: Structure-activity relationships about the 4-alkyl piperidine core

SAR about the piperidine core in a series of MC4R agonists is described. A number of alkyl substituents that furnish compounds with good affinity and functional potency are reported.

PIPERAZINE UREA DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS

Certain novel piperazine urea derivatives are agonists of the human melanocortin-4 receptor (MC-4R) and, in particular, are receptor-subtype selective agonists of MC-4R. They are useful for the treatment, control, or prevention of diseases and disorders r